{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:54:14Z","timestamp":1784865254648,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T00:00:00Z","timestamp":1403136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2014,12]]},"abstract":"\n Increased physical activity is known to be beneficial in people with type 2 diabetes mellitus (\n T2DM<\/jats:styled-content>\n ), but it is not known whether individuals change their activity levels after\n T2DM<\/jats:styled-content>\n diagnosis. The present Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (\n NAVIGATOR<\/jats:styled-content>\n ) trial, conducted in participants with impaired glucose tolerance at high cardiovascular risk, assessed ambulatory activity annually using research\u2010grade pedometers. Oral glucose tolerance tests were performed annually and repeated to confirm\n T2DM<\/jats:styled-content>\n diagnosis. This observational analysis used general linear models to compare step counts before and after\n T2DM<\/jats:styled-content>\n diagnosis in the 2816 participants with the requisite data. Participants were relatively inactive at baseline, taking a median (interquartile range) of 5488 (3258\u20138361) steps\/day, which decreased after\n T2DM<\/jats:styled-content>\n diagnosis by a mean (s.e.) of 258 (64) steps\/day (p < 0.0001); however, after adjusting for background trend for activity, step count after\n T2DM<\/jats:styled-content>\n diagnosis was unchanged [mean (s.e.) of 103 (87) fewer steps\/day; p = 0.23]. Awareness of\n T2DM<\/jats:styled-content>\n diagnosis had no impact on the trajectory of activity established before the diagnosis.\n <\/jats:p>","DOI":"10.1111\/dom.12320","type":"journal-article","created":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T06:36:51Z","timestamp":1401086211000},"page":"1265-1268","source":"Crossref","is-referenced-by-count":5,"title":["Change in levels of physical activity after diagnosis of type 2 diabetes: an observational analysis from the NAVIGATOR study"],"prefix":"10.1111","volume":"16","author":[{"given":"D.","family":"Preiss","sequence":"first","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Haffner","sequence":"additional","affiliation":[{"name":"Department of Medicine Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. E.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010L.","family":"Sun","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Sattar","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Yates","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre University of Leicester Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"J Davies","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre University of Leicester Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"McMurray","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. R.","family":"Holman","sequence":"additional","affiliation":[{"name":"Diabetes Trials Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"Califf","sequence":"additional","affiliation":[{"name":"Duke Translational Medicine Institute Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. E.","family":"Kraus","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012512"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105033441801"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0048"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1212914"},{"key":"e_1_2_7_6_1","unstructured":"WHO. Global recommendations on physical activity for health2010. Available from URL:http:\/\/www.who.int\/dietphysicalactivity\/factsheet_recommendations\/en\/. Accessed 18 December 2013."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-9990"},{"issue":"1","key":"e_1_2_7_8_1","first-page":"S11","article-title":"Standards of medical care in diabetes\u20132012","volume":"35","year":"2012","journal-title":"Diabetes Care"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2002.00835.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001122"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001121"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200434010-00001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181dc2e54"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12320","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T03:20:56Z","timestamp":1761880856000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,19]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/dom.12320"],"URL":"https:\/\/doi.org\/10.1111\/dom.12320","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,19]]}}}