{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:36:17Z","timestamp":1791268577892,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T00:00:00Z","timestamp":1410220800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["3100A0-113525"],"award-info":[{"award-number":["3100A0-113525"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Research Council (INSIGHT)"},{"name":"European Union Framework Program 7 Collaborative Project BetaBat"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>\n                    Intracellular glucose signalling pathways control the secretion of glucagon and insulin by pancreatic islet \u03b1\u2010 and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010cells, respectively. However, glucose also indirectly controls the secretion of these hormones through regulation of the autonomic nervous system that richly innervates this endocrine organ. Both parasympathetic and sympathetic nervous systems also impact endocrine pancreas postnatal development and plasticity in adult animals. Defects in these autonomic regulations impair\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010cell mass expansion during the weaning period and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010cell mass adaptation in adult life. Both branches of the autonomic nervous system also regulate glucagon secretion. In type 2 diabetes, impaired glucose\u2010dependent autonomic activity causes the loss of cephalic and first phases of insulin secretion, and impaired suppression of glucagon secretion in the postabsorptive phase; in diabetic patients treated with insulin, it causes a progressive failure of hypoglycaemia to trigger the secretion of glucagon and other counterregulatory hormones. Therefore, identification of the glucose\u2010sensing cells that control the autonomic innervation of the endocrine pancreatic and insulin and glucagon secretion is an important goal of research. This is required for a better understanding of the physiological control of glucose homeostasis and its deregulation in diabetes. This review will discuss recent advances in this field of investigation.\n                  <\/jats:p>","DOI":"10.1111\/dom.12346","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T05:48:44Z","timestamp":1410241724000},"page":"87-95","source":"Crossref","is-referenced-by-count":137,"title":["Neural regulation of pancreatic islet cell mass and function"],"prefix":"10.1111","volume":"16","author":[{"given":"B.","family":"Thorens","sequence":"first","affiliation":[{"name":"Center for Integrative Genomics University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201023260104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.14.6.750"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28735"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60614-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665110003988"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.06.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65538"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1178"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-12-0278"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.01.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01453.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.10.014"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01450.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-2040"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051322"},{"key":"e_1_2_9_18_1","first-page":"R523","article-title":"Identification 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