{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:49:05Z","timestamp":1784641745555,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>\n                    Inflammation at the level of the \u03b2 cell appears to be involved in progressive \u03b2\u2010cell dysfunction in type 2 diabetes. We assessed the effect of blocking interleukin\u20101 (\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20101) by anakinra [recombinant human interleukin\u20101 receptor antagonist (IL\u20101Ra)] on \u03b2\u2010cell function. Sixteen participants with impaired glucose tolerance were treated with 150 mg anakinra daily for 4 weeks in a double blind, randomized, placebo\u2010controlled cross\u2010over study with a wash\u2010out period of 4 weeks. At the end of each treatment period, oral glucose tolerance tests (\n                    <jats:styled-content style=\"fixed-case\">OGTTs<\/jats:styled-content>\n                    ) and hyperglycaemic clamps were performed. First\u2010phase insulin secretion improved after anakinra treatment compared with placebo, 148 \u00b1 20 versus 123 \u00b1 14 mU\/l, respectively (p = 0.03), and the insulinogenic index was higher after anakinra treatment. These results support the concept of involvement of\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20101\u03b2 in the (progressive) decrease of insulin secretion capacity associated with type 2 diabetes.\n                  <\/jats:p>","DOI":"10.1111\/dom.12357","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T13:19:58Z","timestamp":1405430398000},"page":"1269-1273","source":"Crossref","is-referenced-by-count":57,"title":["The interleukin\u20101 receptor antagonist anakinra improves first\u2010phase insulin secretion and insulinogenic index in subjects with impaired glucose tolerance"],"prefix":"10.1111","volume":"16","author":[{"given":"P. C. M.","family":"van Poppel","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Radboud University Nijmegen Medical Centre  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J. P.","family":"van Asseldonk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Nijmegen Medical Centre  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Holst","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Panum Institute University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Vilsb\u00f8ll","sequence":"additional","affiliation":[{"name":"Department of Medicine Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G.","family":"Netea","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Nijmegen Medical Centre  Nijmegen the Netherlands"},{"name":"Nijmegen Institute for Infection Inflammation and Immunity (N4i)  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"Tack","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (463) Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4065\/78.4.447"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1834"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.11.1249"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0033"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200215318"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065213"},{"key":"e_1_2_7_8_1","first-page":"415","article-title":"Glucose toxicity","volume":"13","author":"Yki\u2010Jarvinen H","year":"1992","journal-title":"Endocr Rev"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-S062"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01549.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2992"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01637.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.3.327"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12357","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T03:20:58Z","timestamp":1761880858000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,13]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/dom.12357"],"URL":"https:\/\/doi.org\/10.1111\/dom.12357","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,13]]}}}