{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:20:54Z","timestamp":1768782054120,"version":"3.49.0"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004323","name":"Amylin Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2015,1]]},"abstract":"\n Aim<\/jats:title>\n \n To test the impact of cholecystokinin (\n CCK<\/jats:styled-content>\n ) plus either amylin or a glucagon\u2010like peptide\u20101 receptor (\n GLP\u20101R<\/jats:styled-content>\n ) agonist on metabolic variables in diet\u2010induced obese (\n DIO<\/jats:styled-content>\n ) rodents.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A stabilized acetylated version of\n CCK<\/jats:styled-content>\n \u20108 (Ac\u2010Y*\u2010\n CCK<\/jats:styled-content>\n \u20108), selective\n CCK1<\/jats:styled-content>\n receptor (\n CCK1R<\/jats:styled-content>\n ) or\n CCK2<\/jats:styled-content>\n receptor (\n CCK2R<\/jats:styled-content>\n ) agonists, amylin or the\n GLP\u20101R<\/jats:styled-content>\n agonist and exenatide analogue\n AC3174<\/jats:styled-content>\n were administered in select combinations via continuous subcutaneous infusion to\n DIO<\/jats:styled-content>\n rats for 14\u2009days, or\n \n Lep\n ob<\/jats:sup>\n \/Lep\n ob<\/jats:sup>\n <\/jats:italic>\n mice for 28\u2009days, and metabolic variables were assessed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Combined administration of Ac\u2010Y*\u2010\n CCK<\/jats:styled-content>\n \u20108 with either amylin or\n AC3174<\/jats:styled-content>\n induced greater than additive weight loss in\n DIO<\/jats:styled-content>\n rats, with the overall magnitude of effect being greater with\n AC3174<\/jats:styled-content>\n \u2009+\u2009Ac\u2010Y*\u2010\n CCK<\/jats:styled-content>\n \u20108 treatment. Co\u2010infusion of\n AC3174<\/jats:styled-content>\n with a specific\n CCK1R<\/jats:styled-content>\n agonist, but not a\n CCK2R<\/jats:styled-content>\n agonist, recapitulated the weight loss mediated by\n AC3174<\/jats:styled-content>\n \u2009+\u2009Ac\u2010Y*\u2010\n CCK<\/jats:styled-content>\n \u20108 in\n DIO<\/jats:styled-content>\n rats, suggesting that synergy is mediated by\n CCK1R<\/jats:styled-content>\n activation. In a 4\u2009\u00d7\u20094 full\u2010factorial response surface methodology study in\n DIO<\/jats:styled-content>\n rats, a synergistic interaction between\n AC3174<\/jats:styled-content>\n and the\n CCK1R<\/jats:styled-content>\n \u2010selective agonist on body weight and food intake was noted. Co\u2010administration of\n AC3174<\/jats:styled-content>\n and the\n CCK1R<\/jats:styled-content>\n \u2010selective agonist to obese diabetic\n \n Lep\n ob<\/jats:sup>\n \/Lep\n ob<\/jats:sup>\n <\/jats:italic>\n mice elicited a significantly greater reduction in percentage of glycated haemoglobin and food intake relative to the sum effects of monotherapy groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The anti\u2010obesity and antidiabetic potential of combined\n GLP\u20101R<\/jats:styled-content>\n and\n CCK1R<\/jats:styled-content>\n agonism is an approach that warrants further investigation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12390","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T04:25:19Z","timestamp":1410323119000},"page":"61-73","source":"Crossref","is-referenced-by-count":57,"title":["Synergistic metabolic benefits of an exenatide analogue and\u00a0cholecystokinin in diet\u2010induced obese and leptin\u2010deficient rodents"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5356-6118","authenticated-orcid":false,"given":"J. 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