{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:44:06Z","timestamp":1762004646723,"version":"build-2065373602"},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>\n                    The aim of the present study was to compare the long\u2010term safety and efficacy of insulin degludec with those of insulin glargine in patients with advanced type 2 diabetes (\n                    <jats:styled-content style=\"fixed-case\">T2D<\/jats:styled-content>\n                    ) over 78\u2009weeks (the 52\u2010week main trial and a 26\u2010week extension). Patients were randomized to once\u2010daily insulin degludec or insulin glargine, with mealtime insulin aspart\u2009\u00b1\u2009metformin\u2009\u00b1\u2009pioglitazone, and titrated to pre\u2010breakfast plasma glucose values of 3.9\u20134.9\u2009mmol\/l  (70\u201388\u2009mg\/dl). After 78\u2009weeks, the overall rate of hypoglycaemia was 24% lower (p\u2009=\u20090.011) and the rate of nocturnal hypoglycaemia was 31% lower (p\u2009=\u20090.016) with insulin degludec in the extension trial set, while both groups of patients achieved similar glycaemic control. Rates of adverse events and total insulin doses were similar for both groups in the safety analysis set. During 18\u2009months of treatment, insulin degludec\u2009+\u2009mealtime insulin aspart\u2009\u00b1\u2009oral antidiabetic drugs in patients with\n                    <jats:styled-content style=\"fixed-case\">T2D<\/jats:styled-content>\n                    improves glycaemic control similarly, but confers lower risks of overall and nocturnal hypoglycaemia than with insulin glargine treatment.\n                  <\/jats:p>","DOI":"10.1111\/dom.12411","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T03:09:06Z","timestamp":1415761746000},"page":"202-206","source":"Crossref","is-referenced-by-count":27,"title":["Insulin degludec improves long\u2010term glycaemic control similarly to insulin glargine but with fewer hypoglycaemic episodes in patients with advanced type 2 diabetes on basal\u2010bolus insulin therapy"],"prefix":"10.1111","volume":"17","author":[{"given":"P.","family":"Hollander","sequence":"first","affiliation":[{"name":"Baylor University Medical Center  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. B.","family":"King","sequence":"additional","affiliation":[{"name":"Diabetes Care Center  Salinas CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Del Prato","sequence":"additional","affiliation":[{"name":"Section of Diabetes, University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sreenan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Connolly Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. K.","family":"Balci","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism, Akdeniz University Faculty of Medicine  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mu\u00f1oz\u2010Torres","sequence":"additional","affiliation":[{"name":"Hospital Universitario San Cecilio  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Rosenstock","sequence":"additional","affiliation":[{"name":"Dallas Diabetes and Endocrine Center  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. T.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Novo Nordisk  S\u00f8borg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Niemeyer","sequence":"additional","affiliation":[{"name":"Novo Nordisk  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Garber","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2014Division of Endocrinology, Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-012-0739-z"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01638.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60205-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01627.x"},{"key":"e_1_2_7_6_1","first-page":"A232","article-title":"Lower within\u2010subject variability in mean blood glucose concentration with insulin degludec vs. insulin glargine: a meta\u2010analysis of patients with T2D","volume":"62","author":"Meneghini LF","year":"2013","journal-title":"Diabetes"},{"key":"e_1_2_7_7_1","first-page":"A106","article-title":"Rate ratios for nocturnal confirmed hypoglycemia with insulin degludec vs. insulin glargine using different definitions","volume":"63","author":"Heller SR","year":"2014","journal-title":"Diabetes"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12411","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.12411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.12411","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:49:09Z","timestamp":1761864549000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,27]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/dom.12411"],"URL":"https:\/\/doi.org\/10.1111\/dom.12411","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"type":"print","value":"1462-8902"},{"type":"electronic","value":"1463-1326"}],"subject":[],"published":{"date-parts":[[2014,11,27]]}}}