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Liraglutide treatment alone also reduced meal size; an effect not enhanced with leptin co\u2010administration. Moderate doses of liraglutide (75\u2009\u00b5g\/kg) and leptin (4\u2009\u00b5g), examined separately, each reduced meal frequency, cumulative food intake and body weight; only liraglutide reduced meal size. In combination these doses did not further enhance the anorexigenic effects of either treatment alone.\n                      <jats:italic>Ex vivo<\/jats:italic>\n                      immunoblot analysis showed elevated\n                      <jats:styled-content style=\"fixed-case\">pSTAT3<\/jats:styled-content>\n                      in the hypothalamic tissue after liraglutide\u2010leptin co\u2010treatment, an effect which was greater than that of leptin treatment alone. In addition, s.c. liraglutide reduced the expression of\n                      <jats:styled-content style=\"fixed-case\">PTP1B<\/jats:styled-content>\n                      (a negative regulator of leptin receptor signalling), revealing a potential mechanism for the enhanced\n                      <jats:styled-content style=\"fixed-case\">pSTAT3<\/jats:styled-content>\n                      response after liraglutide\u2010leptin co\u2010administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Collectively, these results show novel behavioural and molecular mechanisms underlying the additive reduction in food intake and body weight after liraglutide\u2010leptin combination treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.12423","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T17:52:51Z","timestamp":1418061171000},"page":"285-293","source":"Crossref","is-referenced-by-count":38,"title":["Liraglutide, leptin and their combined effects on feeding: additive intake reduction through common intracellular signalling mechanisms"],"prefix":"10.1111","volume":"17","author":[{"given":"S. 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