{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:40:19Z","timestamp":1761871219644,"version":"build-2065373602"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T00:00:00Z","timestamp":1426118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2015,6]]},"abstract":"\n To elucidate whether increased insulin concentration after salsalate treatment (3\u2009g\/day for 7\u2009days) is attributable to an increased insulin secretion rate (\n ISR<\/jats:styled-content>\n ) or to reduced metabolic clearance of endogenous insulin (\n MCI<\/jats:styled-content>\n ) during stepped glucose infusion (\n SGI<\/jats:styled-content>\n ). The analysis was performed in obese subjects who participated in a randomized double\u2010blind, parallel, placebo\u2010controlled clinical trial. A total of 27 participants (16 on salsalate, 11 on placebo) completed baseline and follow\u2010up\n SGI<\/jats:styled-content>\n . During\n SGI<\/jats:styled-content>\n in the salsalate group,\n C<\/jats:styled-content>\n \u2010peptide concentrations were reduced by 11%, while plasma insulin concentrations were increased by 30%, corresponding to a 30% reduction in\n MCI<\/jats:styled-content>\n (p\u2009<\u20090.0001). At molar increments of glucose, insulin concentrations were increased by 27% (p\u2009=\u20090.02), but\n ISR<\/jats:styled-content>\n was unchanged. Salsalate did not alter insulin secretion, but lowered\n MCI<\/jats:styled-content>\n , indicating that a reduction in insulin clearance is the principal mechanism for increased insulin levels after salsalate administration.\n <\/jats:p>","DOI":"10.1111\/dom.12450","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T08:06:50Z","timestamp":1423814810000},"page":"608-612","source":"Crossref","is-referenced-by-count":9,"title":["Salsalate has no effect on insulin secretion but decreases insulin clearance: a randomized, placebo\u2010controlled trial in subjects without diabetes"],"prefix":"10.1111","volume":"17","author":[{"given":"A.","family":"Penesova","sequence":"first","affiliation":[{"name":"Obesity and Diabetes Clinical Research Section Phoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, DHHS Phoenix AZ USA"},{"name":"Centre of Molecular Medicine, Institute of Experimental Endocrinology, Slovak Academy of Sciences Bratislava Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Koska","sequence":"additional","affiliation":[{"name":"Obesity and Diabetes Clinical Research Section Phoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, DHHS Phoenix AZ USA"},{"name":"Phoenix VA Health Care System Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Ortega","sequence":"additional","affiliation":[{"name":"Obesity and Diabetes Clinical Research Section Phoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, DHHS Phoenix AZ USA"},{"name":"Department of Endocrinology and Nutrition ICMDM, Hospital Clinic, IDIBAPS, CIBEROBN Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Bunt","sequence":"additional","affiliation":[{"name":"Obesity and Diabetes Clinical Research Section Phoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, DHHS Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bogardus","sequence":"additional","affiliation":[{"name":"Obesity and Diabetes Clinical Research Section Phoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, DHHS Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"de Courten","sequence":"additional","affiliation":[{"name":"Obesity and Diabetes Clinical Research Section Phoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, DHHS Phoenix AZ USA"},{"name":"Monash Centre for Health, Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1212"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1239-x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2819-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2977"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-6-1102"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00291974"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01228129"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.27.12.1196"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.27.7.750"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.8.1828"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.41.3.368"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2003.10719326"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12450","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.12450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.12450","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:31:56Z","timestamp":1761870716000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,12]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/dom.12450"],"URL":"https:\/\/doi.org\/10.1111\/dom.12450","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"type":"print","value":"1462-8902"},{"type":"electronic","value":"1463-1326"}],"subject":[],"published":{"date-parts":[[2015,3,12]]}}}