{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T17:30:14Z","timestamp":1778434214971,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T00:00:00Z","timestamp":1433721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2015,8]]},"abstract":"\n Aim<\/jats:title>\n To examine real\u2010life time trends in early glycaemic control in patients with type 2 diabetes between 2000 and 2012.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We used population\u2010based medical databases to ascertain the association between achievement of glycaemic control with initial glucose\u2010lowering treatment in patients with incident type 2 diabetes in\n N<\/jats:styled-content>\n orthern\n D<\/jats:styled-content>\n enmark. Success in reaching glycated haemoglobin (\n HbA1c<\/jats:styled-content>\n ) goals within 3\u20136\u2009months was examined using regression analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 38\u2009418 patients, 91% started with oral glucose\u2010lowering drugs in monotherapy. Metformin initiation increased from 32% in 2000\u20132003 to 90% of all patients in 2010\u20132012. Pretreatment (interquartile range)\n HbA1c<\/jats:styled-content>\n levels decreased from 8.9 (7.6\u201310.7)% in 2000\u20132003 to 7.0 (6.5\u20138.1)% in 2010\u20132012. More patients achieved an\n HbA1c<\/jats:styled-content>\n target of <7% (<53\u2009mmol\/mol) in 2010\u20132012 than in 2000\u20132003 [80 vs 60%, adjusted relative risk (\n aRR<\/jats:styled-content>\n ) 1.10, 95% confidence interval (\n CI<\/jats:styled-content>\n ) 1.08\u20131.13], and more achieved an\n HbA1c<\/jats:styled-content>\n target of <6.5% [(<48\u2009mmol\/mol) 53 vs 37%,\n aRR<\/jats:styled-content>\n 1.07 95%\n CI<\/jats:styled-content>\n 1.03\u20131.11)], with similar success rates observed among patients aged <65\u2009years without comorbidities. Achieved\n HbA1c<\/jats:styled-content>\n levels were similar for different initiation therapies, with reductions of 0.8% (from 7.3 to 6.5%) on metformin, 1.5% (from 8.1 to 6.6%) on sulphonylurea, 4.0% (from 10.4 to 6.4%) on non\u2010insulin combination therapies, and 3.8% (from 10.3 to 6.5%) on insulin monotherapy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Pretreatment\n HbA1c<\/jats:styled-content>\n levels in patients with incident type 2 diabetes have decreased substantially, which is probably related to earlier detection and treatment in accordance with changing guidelines. Achievement of glycaemic control has improved, but 20% of patients still do not attain an\n HbA1c<\/jats:styled-content>\n level of <7% within the first 6\u2009months of initial treatment.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12484","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T05:51:05Z","timestamp":1430373065000},"page":"771-780","source":"Crossref","is-referenced-by-count":34,"title":["Early glycaemic control among patients with type 2 diabetes and initial glucose\u2010lowering treatment: a 13\u2010year population\u2010based cohort study"],"prefix":"10.1111","volume":"17","author":[{"given":"R. W.","family":"Thomsen","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine, Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. M.","family":"Baggesen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine, Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine, Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine, Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"N\u00f8rrelund","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine, Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. S.","family":"Buhl","sequence":"additional","affiliation":[{"name":"Novo Nordisk Scandinavia AB \u00d8restad Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L.","family":"Haase","sequence":"additional","affiliation":[{"name":"Novo Nordisk Scandinavia AB \u00d8restad Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P.","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Institute of Clinical Medicine, Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07037-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806470"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802987"},{"key":"e_1_2_7_5_1","first-page":"CD008143","article-title":"Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus","author":"Hemmingsen B","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802743"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.04.014"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-S014"},{"key":"e_1_2_7_9_1","unstructured":"The Danish College of General Practitioners (DSAM) and the Danish Endocrine Society (DES).Guidelines for type 2\u2010diabetes 2014 revision. Farmakologisk behandling af type 2\u2010diabetes. [in Danish]. Available from URL:http:\/\/www.dsam.dk\/flx\/publikationer\/. 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