{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:22:32Z","timestamp":1792142552057,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T00:00:00Z","timestamp":1434412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2015,9]]},"abstract":"\n Aims<\/jats:title>\n \n To conduct a patient\u2010level meta\u2010analysis of the\n EDITION<\/jats:styled-content>\n 1, 2 and 3 studies, which compared the efficacy and safety of new insulin glargine 300 U\/ml (\n G<\/jats:styled-content>\n la\u2010300) with insulin glargine 100 U\/ml (\n G<\/jats:styled-content>\n la\u2010100) in people with type 2 diabetes (\n T2DM<\/jats:styled-content>\n ) on basal and mealtime insulin, basal insulin and oral antihyperglycaemic drugs, or no prior insulin, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The\n EDITION<\/jats:styled-content>\n studies were multicentre, randomized, open\u2010label, parallel\u2010group, phase\n IIIa<\/jats:styled-content>\n studies, with similar designs and endpoints. A patient\u2010level meta\u2010analysis of the studies enabled these endpoints to be examined over 6 months in a large population with\n T2DM<\/jats:styled-content>\n (\n G<\/jats:styled-content>\n la\u2010300, n = 1247;\n G<\/jats:styled-content>\n la\u2010100, n = 1249).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n No significant study\u2010by\u2010treatment interactions across studies were found, enabling them to be pooled. The mean change in glycated haemoglobin was comparable for\n G<\/jats:styled-content>\n la\u2010300 and\n G<\/jats:styled-content>\n la\u2010100 [each \u22121.02 (standard error 0.03)%; least squares (\n LS<\/jats:styled-content>\n ) mean difference 0.00 (95% confidence interval (CI) \u22120.08 to 0.07)%]. Annualized rates of confirmed (\u22643.9 mmol\/l) or severe hypoglycaemia were lower with\n G<\/jats:styled-content>\n la\u2010300 than with\n G<\/jats:styled-content>\n la\u2010100 during the night (31% difference in rate ratio over 6 months) and at any time (24 h, 14% difference). Consistent reductions were observed in percentage of participants with \u22651 hypoglycaemic event. Severe hypoglycaemia at any time (24 h) was rare (\n G<\/jats:styled-content>\n la\u2010300: 2.3%;\n G<\/jats:styled-content>\n la\u2010100: 2.6%). Weight gain was low (<1 kg) in both groups, with less gain with\n G<\/jats:styled-content>\n la\u2010300 [\n LS<\/jats:styled-content>\n mean difference \u22120.28 kg (95% CI \u22120.55 to \u22120.01); p = 0.039]. Both treatments were well tolerated, with similar rates of adverse events.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Gla\u2010300 provides comparable glycaemic control to\n G<\/jats:styled-content>\n la\u2010100 in a large population with a broad clinical spectrum of\n T2DM<\/jats:styled-content>\n , with consistently less hypoglycaemia at any time of day and less nocturnal hypoglycaemia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12485","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T04:53:29Z","timestamp":1430369609000},"page":"859-867","source":"Crossref","is-referenced-by-count":205,"title":["Patient\u2010level meta\u2010analysis of the\n EDITION<\/scp>\n 1, 2 and 3 studies: glycaemic control and hypoglycaemia with new insulin glargine 300 U\/ml versus glargine 100 U\/ml in people with type 2 diabetes"],"prefix":"10.1111","volume":"17","author":[{"given":"R.","family":"Ritzel","sequence":"first","affiliation":[{"name":"Klinikum Schwabing, St\u00e4dtisches Klinikum M\u00fcnchen GmbH Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Roussel","sequence":"additional","affiliation":[{"name":"Diabetology Endocrinology Nutrition DHU FIRE, Bichat Hospital, Assistance Publique H\u00f4pitaux de Paris Paris France"},{"name":"INSERM U1138, Centre de Recherche des Cordeliers Paris France"},{"name":"UFR de M\u00e9decine Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. B.","family":"Bolli","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Vinet","sequence":"additional","affiliation":[{"name":"EXPERIS IT Nanterre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Brulle\u2010Wohlhueter","sequence":"additional","affiliation":[{"name":"Sanofi Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Glezer","sequence":"additional","affiliation":[{"name":"Sanofi Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yki\u2010J\u00e4rvinen","sequence":"additional","affiliation":[{"name":"Division of Diabetes Faculty of Medicine and Helsinki University Central Hospital, University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1110560"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0413"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905479"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0991"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0990"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12438"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.2337\/dc14-0006","article-title":"New insulin glargine 300 units.mL\u20101 provides a more even activity profile and prolonged glycemic control at steady state compared with insulin glargine 100 units.mL\u20101","volume":"38","author":"Becker RH","year":"2015","journal-title":"Diabetes Care"},{"key":"e_1_2_7_9_1","volume-title":"Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation. 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