{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:08:46Z","timestamp":1789985326431,"version":"4.0.1"},"reference-count":81,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>\n                    Several hormones are regulated by circadian rhythms to adjust the metabolism to the light\/dark cycles and feeding\/activity patterns throughout the day. Circadian rhythms are mainly governed by the central clock located in the suprachiasmatic nucleus but also by clocks present in peripheral organs, like the endocrine pancreas. Plasma glucose levels and the main pancreatic hormones insulin and glucagon also exhibit daily variations. Alterations in circadian rhythms are associated with metabolic disturbances and pathologies such as obesity and diabetes. The molecular components of central and peripheral clocks and their regulatory mechanisms are well established. Among the different clock genes,\n                    <jats:italic>Rev\u2010erb\u03b1<\/jats:italic>\n                    is considered one of the key links between circadian rhythms and metabolism.\n                    <jats:italic>Rev\u2010erb\u03b1<\/jats:italic>\n                    is a critical part of a negative feedback loop in the core circadian clock and modulates the clock oscillatory properties. In addition,\n                    <jats:italic>Rev\u2010erb\u03b1<\/jats:italic>\n                    plays an important role in the regulation of lipid and glucose metabolism, thermogenesis, adipocyte and muscle differentiation as well as mitochondrial function. In the endocrine pancreas,\n                    <jats:italic>Rev\u2010erb\u03b1<\/jats:italic>\n                    regulates insulin and glucagon secretion and pancreatic \u03b2\u2010cell proliferation. In the present review, we discuss all these subjects and, particularly, the role of the clock gene\n                    <jats:italic>Rev\u2010erb\u03b1<\/jats:italic>\n                    in the endocrine pancreas.\n                  <\/jats:p>","DOI":"10.1111\/dom.12522","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T13:13:47Z","timestamp":1441199627000},"page":"106-114","source":"Crossref","is-referenced-by-count":27,"title":["Role of the clock gene\n                    <i>Rev\u2010erb\u03b1<\/i>\n                    in metabolism and in the endocrine pancreas"],"prefix":"10.1111","volume":"17","author":[{"given":"E.","family":"Vieira","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Genetic State University of Maring\u00e1  Maring\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Merino","sequence":"additional","affiliation":[{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM) and Instituto de Bioingenier\u00eda Universidad Miguel Hernandez  Elche Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Quesada","sequence":"additional","affiliation":[{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM) and Instituto de Bioingenier\u00eda Universidad Miguel Hernandez  Elche 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