{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:12:05Z","timestamp":1776895925045,"version":"3.51.2"},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T00:00:00Z","timestamp":1439942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP\u2010115056"],"award-info":[{"award-number":["MOP\u2010115056"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>\n                    Increasing evidence points to the cytotoxicity of islet amyloid polypeptide (\n                    <jats:styled-content style=\"fixed-case\">IAPP<\/jats:styled-content>\n                    ) aggregates as a major contributor to the loss of \u03b2\u2010cell mass in type 2 diabetes. Prevention of\n                    <jats:styled-content style=\"fixed-case\">IAPP<\/jats:styled-content>\n                    formation represents a potential treatment to increase \u03b2\u2010cell survival and function. The\n                    <jats:styled-content style=\"fixed-case\">IAPP<\/jats:styled-content>\n                    inhibitory peptide,\n                    <jats:styled-content style=\"fixed-case\">D\u2010ANFLVH<\/jats:styled-content>\n                    , has been previously shown to prevent islet amyloid accumulation in cultured human islets. To assess its activity\n                    <jats:italic>in vivo<\/jats:italic>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">D\u2010ANFLVH<\/jats:styled-content>\n                    was administered by intraperitoneal injection into a human\n                    <jats:styled-content style=\"fixed-case\">IAPP<\/jats:styled-content>\n                    transgenic mouse model, which replicates type 2 diabetes islet amyloid pathology. The peptide was a potent inhibitor of islet amyloid deposition, resulting in reduced islet cell apoptosis and preservation of \u03b2\u2010cell area leading to improved glucose tolerance. These findings provide support for a key role of islet amyloid in \u03b2\u2010cell survival and validate the application of anti\u2010amyloid compounds as therapeutic strategies to maintain normal insulin secretion in patients with type 2 diabetes.\n                  <\/jats:p>","DOI":"10.1111\/dom.12529","type":"journal-article","created":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T02:50:31Z","timestamp":1434941431000},"page":"1003-1006","source":"Crossref","is-referenced-by-count":23,"title":["Islet amyloid inhibitors improve glucose homeostasis in a transgenic mouse model of type 2 diabetes"],"prefix":"10.1111","volume":"17","author":[{"given":"N.","family":"Wijesekara","sequence":"first","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ahrens","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Wu","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ha","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. B.","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. E.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto  Toronto Canada"},{"name":"Department of Medical Biophysics University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01657.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0037"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-251744"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1304-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.47.3.225"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00164-X"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.4593"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.02.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.14.7283"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(02)00265-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend-4-8-1192"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12529","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:24:48Z","timestamp":1761870288000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,19]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/dom.12529"],"URL":"https:\/\/doi.org\/10.1111\/dom.12529","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,19]]}}}