{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:04:39Z","timestamp":1773324279569,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T00:00:00Z","timestamp":1444003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL085251"],"award-info":[{"award-number":["HL085251"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL073410"],"award-info":[{"award-number":["HL073410"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL068986"],"award-info":[{"award-number":["HL068986"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K08HL116640"],"award-info":[{"award-number":["K08HL116640"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>\n                    We conducted a population\u2010based case\u2013control study to assess the myocardial infarction (\n                    <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                    ) and stroke risks associated with sulphonylureas and insulin when used in combination with metformin. Cases had type 2 diabetes and used metformin + insulin or metformin + sulphonylureas at the time of a first\n                    <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                    or first stroke between 1995 and 2010; controls used the same treatment combinations and were randomly sampled from the same population.\n                    <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                    and stroke diagnoses and potential confounders were validated by medical record reviews. Compared with metformin + sulphonylurea, metformin + insulin was associated with similar risks of\n                    <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                    or stroke [odds ratio 0.98 (95% confidence interval 0.63\u20131.52)]. Meta\u2010analysis with another observational study improved the precision of the risk estimate [relative risk 0.92 (95% confidence interval 0.69\u20131.24)]. Current evidence suggests that there may not be large differences in cardiovascular risk associated with the use of insulin or sulphonylureas when used in combination with metformin.\n                  <\/jats:p>","DOI":"10.1111\/dom.12537","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T10:59:53Z","timestamp":1436871593000},"page":"1194-1197","source":"Crossref","is-referenced-by-count":6,"title":["Case\u2013control study of second\u2010line therapies for type 2 diabetes in combination with metformin and the comparative risks of myocardial infarction and stroke"],"prefix":"10.1111","volume":"17","author":[{"given":"J. S.","family":"Floyd","sequence":"first","affiliation":[{"name":"Cardiovascular Health Research Unit University of Washington  Seattle WA USA"},{"name":"Department of Medicine University of Washington  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. L.","family":"Wiggins","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit University of Washington  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Sitlani","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit University of Washington  Seattle WA USA"},{"name":"Department of Medicine University of Washington  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Flory","sequence":"additional","affiliation":[{"name":"Department of Healthcare Policy and Research Weill Cornell Medical College  New York NY USA"},{"name":"Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Dublin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Washington  Seattle WA USA"},{"name":"Group Health Research Institute  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit University of Washington  Seattle WA USA"},{"name":"Department of Epidemiology University of Washington  Seattle WA USA"},{"name":"Group Health Research Institute  Seattle WA USA"},{"name":"Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Heckbert","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit University of Washington  Seattle WA USA"},{"name":"Department of Epidemiology University of Washington  Seattle WA USA"},{"name":"Group Health Research Institute  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. M.","family":"Psaty","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit University of Washington  Seattle WA USA"},{"name":"Department of Medicine University of Washington  Seattle WA USA"},{"name":"Department of Epidemiology University of Washington  Seattle WA USA"},{"name":"Group Health Research Institute  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0413"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60794-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.4312"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c103"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781439821862"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112220"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780101105"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9899-y"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203858"},{"key":"e_1_2_7_12_1","first-page":"789","article-title":"A study of the effects of hypoglycemic agents on vascular complications in patients with adult\u2010onset diabetes. 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Mortality results","volume":"19","author":"Meinert CL","year":"1970","journal-title":"Diabetes"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1307684"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0356"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-2082"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12537","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:07:44Z","timestamp":1761862064000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,5]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/dom.12537"],"URL":"https:\/\/doi.org\/10.1111\/dom.12537","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,5]]}}}