{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:30:06Z","timestamp":1767850206683,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T00:00:00Z","timestamp":1445817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF\u20102011\u20100009540"],"award-info":[{"award-number":["NRF\u20102011\u20100009540"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    We hypothesized that the pharmacodynamic (\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    ) characteristics of metformin would change with inhibition of the multidrug and toxin extrusion (\n                    <jats:styled-content style=\"fixed-case\">MATE<\/jats:styled-content>\n                    ) transporter, which mediates renal elimination of metformin. Twenty healthy male subjects received two doses (750\/500\u2009mg) of metformin, with and without 50\u2009mg of pyrimethamine (a potent\n                    <jats:styled-content style=\"fixed-case\">MATE<\/jats:styled-content>\n                    inhibitor), with 1\u2009week of washout in between each dose. The\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    characteristics of metformin were assessed using oral glucose tolerance tests (\n                    <jats:styled-content style=\"fixed-case\">OGTTs<\/jats:styled-content>\n                    ) before and after the metformin dose. Metformin concentrations in plasma and urine were determined using liquid chromatography\u2010electrospray ionization\u2010tandem mass spectrometry. When metformin was co\u2010administered with pyrimethamine, its area under the concentration\u2013time curve from 0 to 12\u2009h was 2.58\u2010fold greater (p\u2009&lt;\u20090.05), whereas the antihyperglycaemic effects of metformin were decreased. The mean differences (90% confidence interval) in mean and maximum serum glucose concentrations and in 2\u2010h\u2010post\u2010\n                    <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>\n                    serum glucose concentration were \u22120.6 (\u22121, \u22120.2), \u22120.9 (\u22121.6, \u22120.3) and \u22120.5 (\u22121.1, 0.1)\u2009mmol\/l, respectively. These findings indicate that the response to metformin is not only related to the plasma exposure of metformin but is also related to other factors, such as inhibition of uptake transporters and the gastrointestinal\u2010based pharmacology of metformin.\n                  <\/jats:p>","DOI":"10.1111\/dom.12577","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T05:53:10Z","timestamp":1442555590000},"page":"104-108","source":"Crossref","is-referenced-by-count":38,"title":["Inhibition of the multidrug and toxin extrusion (\n                    <scp>MATE<\/scp>\n                    ) transporter by pyrimethamine increases the plasma concentration of metformin but does not increase antihyperglycaemic activity in humans"],"prefix":"10.1111","volume":"18","author":[{"given":"J.","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010I.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010Y.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. H.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.\u2010J.","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.\u2010S.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010Y.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Bundang Hospital  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2004.00448.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11808"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/009127009603601105"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2015.05.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.36"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.163642"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1128\/AAC.40.6.1360","article-title":"Pyrimethamine pharmacokinetics in human immunodeficiency virus\u2010positive patients seropositive for Toxoplasma gondii","volume":"40","author":"Jacobson JM","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1208\/ps040425"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1985.tb05034.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.30.8.861"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100778"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/S0021-9258(18)69818-7","article-title":"Effect of pyrimethamine on folic acid metabolism in streptococcus faecalis and Escherichia coli","volume":"234","author":"Wood RC","year":"1959","journal-title":"J Biol Chem"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9177-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0270085"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01449.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.266"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12476"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12577","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:35:19Z","timestamp":1761863719000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,26]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/dom.12577"],"URL":"https:\/\/doi.org\/10.1111\/dom.12577","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,26]]}}}