{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:45:44Z","timestamp":1762004744445,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2016,2]]},"abstract":"\n Aims<\/jats:title>\n \n To examine the relationships between glycated haemoglobin (\n HbA1c<\/jats:styled-content>\n ) and cardiovascular (\n CV<\/jats:styled-content>\n ) events in people beginning insulin in routine clinical practice in\n E<\/jats:styled-content>\n urope,\n N<\/jats:styled-content>\n orth\n A<\/jats:styled-content>\n merica and\n A<\/jats:styled-content>\n sia in a non\u2010interventional study, the\n C<\/jats:styled-content>\n ardiovascular\n R<\/jats:styled-content>\n isk\n E<\/jats:styled-content>\n valuation in people with\n T<\/jats:styled-content>\n ype 2\n D<\/jats:styled-content>\n iabetes on\n I<\/jats:styled-content>\n nsulin\n T<\/jats:styled-content>\n herapy (\n CREDIT<\/jats:styled-content>\n ) study.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Data on 2999 people were collected prospectively over 4\u2009years from physician reports. The primary outcome was the composite of stroke or myocardial infarction (\n MI<\/jats:styled-content>\n ) or\n CV<\/jats:styled-content>\n \u2010specific death. Events were blindly adjudicated. The relative hazards of\n CV<\/jats:styled-content>\n events were described from\n C<\/jats:styled-content>\n ox proportional hazards models incorporating patient risk factors, with updated average\n HbA1c<\/jats:styled-content>\n as a time\u2010dependent covariate. The relationship of severe and symptomatic hypoglycaemia (collected during the 6\u2009months before yearly ascertainment) with\n CV<\/jats:styled-content>\n and all\u2010cause mortality was examined.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 147 primary events were accrued during up to 54\u2009months of follow\u2010up. In all, 60\n CV<\/jats:styled-content>\n \u2010specific deaths, 44 non\u2010fatal\n MIs<\/jats:styled-content>\n and 57 non\u2010fatal strokes occurred, totalling 161 events. There was a significant positive relationship between updated mean\n HbA1c<\/jats:styled-content>\n and primary outcome: hazard ratio (\n HR<\/jats:styled-content>\n ) 1.25 [95% confidence interval (\n CI<\/jats:styled-content>\n ) 1.12\u20131.40; p\u2009<\u20090.0001].\n CV<\/jats:styled-content>\n death [\n HR<\/jats:styled-content>\n 1.31 (95%\n CI<\/jats:styled-content>\n 1.10\u20131.57); p\u2009=\u20090.0027] and stroke [\n HR<\/jats:styled-content>\n 1.36 (95%\n CI<\/jats:styled-content>\n 1.17\u20131.59); p\u2009<\u20090.0001] were both strongly associated with\n HbA1c<\/jats:styled-content>\n , while\n MI<\/jats:styled-content>\n was not [\n HR<\/jats:styled-content>\n 1.05 (95%\n CI<\/jats:styled-content>\n 0.83\u20131.32)]. One or more severe hypoglycaemic episodes affected 175 participants, while 1508 participants experienced one or more symptomatic hypoglycaemic events. We found no relationship between severe\/symptomatic hypoglycaemic events and\n CV<\/jats:styled-content>\n \u2010specific\/all\u2010cause death.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Ongoing poorer glucose control was associated with\n CV<\/jats:styled-content>\n events; hypoglycaemia was not associated with\n CV<\/jats:styled-content>\n \u2010specific\/all\u2010cause death.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12598","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T03:51:30Z","timestamp":1446090690000},"page":"152-158","source":"Crossref","is-referenced-by-count":29,"title":["Relationship of glycaemic control and hypoglycaemic episodes to 4\u2010year cardiovascular outcomes in people with type 2 diabetes starting insulin"],"prefix":"10.1111","volume":"18","author":[{"given":"N.","family":"Freemantle","sequence":"first","affiliation":[{"name":"Department of Primary Care and Population Health University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Danchin","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Paris Ren\u00e9 Descartes Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Calvi\u2010Gries","sequence":"additional","affiliation":[{"name":"AtlanStat Rez\u00e9 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Vincent","sequence":"additional","affiliation":[{"name":"Sanofi Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. D.","family":"Home","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine\u2010Diabetes, Newcastle University Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67528-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808431"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802743"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802987"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.10.021"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1278"},{"key":"e_1_2_7_8_1","first-page":"A98","article-title":"The relationship between insulin exposure and cardiovascular mortality in the ACCORD trial","volume":"62","author":"Siraj ES","year":"2013","journal-title":"Diabetes"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4909"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003795"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-3010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12147"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01613.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2015.01.030"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203858"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2554"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-3115-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7258.405"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1470-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60611-5"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414266"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806470"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60697-8"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht332"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02438.x"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12598","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.12598","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.12598","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T05:04:22Z","timestamp":1761887062000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,23]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/dom.12598"],"URL":"https:\/\/doi.org\/10.1111\/dom.12598","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"type":"print","value":"1462-8902"},{"type":"electronic","value":"1463-1326"}],"subject":[],"published":{"date-parts":[[2015,12,23]]}}}