{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:48:26Z","timestamp":1765608506010,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T00:00:00Z","timestamp":1453939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2016,4]]},"abstract":"\n Aim<\/jats:title>\n \n To investigate the effects of extended\u2010release (\n ER<\/jats:styled-content>\n ) niacin on apolipoprotein B\u201048 (\n apoB<\/jats:styled-content>\n \u201048) kinetics in statin\u2010treated patients with type 2 diabetes (\n T2DM<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 12 men with\n T2DM<\/jats:styled-content>\n were randomized to rosuvastatin or rosuvastatin plus\n ER<\/jats:styled-content>\n niacin for 12 weeks and then crossed to the alternate therapy. Postprandial metabolic studies were performed at the end of each treatment period.\n D3<\/jats:styled-content>\n \u2010leucine tracer was administered as subjects consumed a high\u2010fat liquid meal.\n ApoB<\/jats:styled-content>\n \u201048 kinetics were determined using stable isotope tracer kinetics with fractional catabolic rates (\n FCRs<\/jats:styled-content>\n ) and secretion rates derived using a non\u2010steady\u2010state compartmental model. Area\u2010under\u2010the\u2010curve (\n AUC<\/jats:styled-content>\n ) and incremental\n AUC<\/jats:styled-content>\n (\n iAUC<\/jats:styled-content>\n ) for plasma triglyceride and\n apoB<\/jats:styled-content>\n \u201048 were also calculated over the 10\u2010h period after ingestion of the fat meal.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In statin\u2010treated patients with\n T2DM<\/jats:styled-content>\n ,\n apoB<\/jats:styled-content>\n \u201048 concentration was lower with\n ER<\/jats:styled-content>\n niacin (8.24 \u00b1 1.98 vs 5.48 \u00b1 1.14 mg\/l, p = 0.03) compared with statin alone. Postprandial triglyceride and\n apoB<\/jats:styled-content>\n \u201048\n AUC<\/jats:styled-content>\n were also significantly lower on\n ER<\/jats:styled-content>\n niacin treatment (\u201015 and \u201026%, respectively; p < 0.05), without any change to triglyceride and\n apoB<\/jats:styled-content>\n \u201048\n iAUC<\/jats:styled-content>\n .\n ApoB<\/jats:styled-content>\n \u201048 secretion rate in the basal state (3.21 \u00b1 0.34 vs 2.50 \u00b1 0.31 mg\/kg\/day; p = 0.04) and number of\n apoB<\/jats:styled-content>\n \u201048\u2010containing particles secreted in response to the fat load (1.35 \u00b1 0.19 vs 0.84 \u00b1 0.12 mg\/kg; p = 0.02) were lower on\n ER<\/jats:styled-content>\n niacin.\n ApoB<\/jats:styled-content>\n \u201048\n FCR<\/jats:styled-content>\n was not altered with\n ER<\/jats:styled-content>\n niacin (8.78 \u00b1 1.04 vs 9.17 \u00b1 1.26 pools\/day; p = 0.79).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n ER<\/jats:styled-content>\n niacin reduces\n apoB<\/jats:styled-content>\n \u201048 concentration by lowering fasting and postprandial\n apoB<\/jats:styled-content>\n \u201048 secretion rate. This effect may be beneficial for lowering atherogenic postprandial lipoproteins and may provide cardiovascular disease risk benefit in patients with\n T2DM<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12622","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T03:04:59Z","timestamp":1450407899000},"page":"384-391","source":"Crossref","is-referenced-by-count":11,"title":["Effect of niacin on triglyceride\u2010rich lipoprotein apolipoprotein B\u201048 kinetics in statin\u2010treated patients with type 2 diabetes"],"prefix":"10.1111","volume":"18","author":[{"given":"J.","family":"Pang","sequence":"first","affiliation":[{"name":"Metabolic Research Centre, School of Medicine and Pharmacology University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Metabolic Research Centre, School of Medicine and Pharmacology University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Metabolic Research Centre, School of Medicine and Pharmacology University of Western Australia Perth Western Australia Australia"},{"name":"Combined Universities Centre for Rural Health, University of Western Australia Geraldton Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. S.","family":"Tenneti","sequence":"additional","affiliation":[{"name":"Metabolic Research Centre, School of Medicine and Pharmacology University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. F.","family":"Watts","sequence":"additional","affiliation":[{"name":"Metabolic Research Centre, School of Medicine and Pharmacology University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. H. R.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Metabolic Research Centre, School of Medicine and Pharmacology University of Western Australia Perth Western Australia Australia"},{"name":"Faculty of Engineering, Computing and Mathematics University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet1066"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3132\/dvdr.2008.046"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000146267.71816.30"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1111-y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.3.588"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200210000-00001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M600548-JLR200"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00448-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00585-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-003-0109-x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011083231901"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.09.013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248410361337"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011090"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000148955.19792.8D"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X148508"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107579"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht055"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302019"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)30177-2"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2477"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00399800"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00364-0"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000222015.76038.14"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(98)00218-4"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2007.09.008"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.11.001"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802287"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.164541"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13018"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302993"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M008144"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(97)90198-0"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.10.1263"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.14.1568"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.023"}],"container-title":["Diabetes, 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