{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:02:49Z","timestamp":1791277369051,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T00:00:00Z","timestamp":1458259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Handok Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>\n                    We assessed the 24\u2010week efficacy and safety of teneligliptin, a novel dipeptidyl peptidase\u20104 inhibitor, in\n                    <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>\n                    orean patients with type 2 diabetes mellitus (\n                    <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>\n                    ) that was inadequately controlled with diet and exercise. The present study was designed as a multicentre, randomized, double\u2010blind, placebo\u2010controlled, parallel\u2010group, phase\n                    <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n                    study. Patients (n\u2009=\u2009142) were randomized 2\u2009:\u20091 into two different treatment groups as follows: 99 received teneligliptin (20\u2009mg) and 43 received placebo. The primary endpoint was change in glycated haemoglobin (\n                    <jats:styled-content style=\"fixed-case\">HbA1c<\/jats:styled-content>\n                    ) level from baseline to week 24. Teneligliptin significantly reduced the\n                    <jats:styled-content style=\"fixed-case\">HbA1c<\/jats:styled-content>\n                    level from baseline compared with placebo after 24\u2009weeks. At week 24, the differences between changes in\n                    <jats:styled-content style=\"fixed-case\">HbA1c<\/jats:styled-content>\n                    and fasting plasma glucose (\n                    <jats:styled-content style=\"fixed-case\">FBG<\/jats:styled-content>\n                    ) in the teneligliptin and placebo groups were \u22120.94% [least\u2010squares (\n                    <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>\n                    ) mean \u22121.22, \u22120.65] and \u22121.21\u2009mmol\/l (\u22121.72, \u22120.70), respectively (all p\u2009&lt;\u20090.001). The incidence of hypoglycaemia and adverse events were not significantly different between the two groups. This phase\n                    <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n                    , randomized, placebo\u2010controlled study provides evidence of the safety and efficacy of 24\u2009weeks of treatment with teneligliptin as a monotherapy in\n                    <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>\n                    orean patients with\n                    <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/dom.12631","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T14:39:49Z","timestamp":1452436789000},"page":"528-532","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy and safety of teneligliptin, a novel dipeptidyl peptidase\u20104 inhibitor, in\n                    <scp>K<\/scp>\n                    orean patients with type 2 diabetes mellitus: a 24\u2010week multicentre, randomized, double\u2010blind, placebo\u2010controlled phase\n                    <scp>III<\/scp>\n                    trial"],"prefix":"10.1111","volume":"18","author":[{"given":"S.","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, College of Medicine Hanyang University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010Y.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Eulji University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. H.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J.","family":"Ku","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine Chungnam National University College of Medicine  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. W.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. K.","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Boramae Medical Center Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. S.","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Uijeognbu St. Mary's Hospital Catholic University Medical College  Uijeongbu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. B.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine Hanyang University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010W.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, CHA Bungdang Medical Center CHA University College of Medicine  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010W.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2012.36.5.336"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.15.6.540"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2441"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01662.x"},{"key":"e_1_2_7_6_1","first-page":"CD006739","article-title":"Dipeptidyl peptidase\u20104 (DPP\u20104) inhibitors for type 2 diabetes mellitus","volume":"2","author":"Richter B","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2008.00876.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12092"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12424"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0703"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990903178735"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2006.12.009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2014.38.6.426"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1639"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1135"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2010.01350.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1035"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-s223"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12631","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12631","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:24:13Z","timestamp":1761873853000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,18]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/dom.12631"],"URL":"https:\/\/doi.org\/10.1111\/dom.12631","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,18]]}}}