{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:27:39Z","timestamp":1783517259092,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000382","name":"Society for Endocrinology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2016,5]]},"abstract":"\n Aims<\/jats:title>\n \n To investigate the anorectic effect of\n L<\/jats:styled-content>\n \u2010arginine (\n L\u2010A<\/jats:styled-content>\n rg) in rodents.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We investigated the effects of\n L\u2010A<\/jats:styled-content>\n rg on food intake, and the role of the anorectic gut hormones glucagon\u2010like peptide\u20101 (\n GLP<\/jats:styled-content>\n \u20101) and peptide\n YY<\/jats:styled-content>\n (\n PYY<\/jats:styled-content>\n ), the\n G<\/jats:styled-content>\n \u2010protein\u2010coupled receptor family\n C<\/jats:styled-content>\n group 6 member\n A<\/jats:styled-content>\n (\n GPRC6A<\/jats:styled-content>\n ) and the vagus nerve in mediating these effects in rodents.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Oral gavage of\n L\u2010A<\/jats:styled-content>\n rg reduced food intake in rodents, and chronically reduced cumulative food intake in diet\u2010induced obese mice. Lack of the\n GPRC6A<\/jats:styled-content>\n in mice and subdiaphragmatic vagal deafferentation in rats did not influence these anorectic effects. L\u2010\n A<\/jats:styled-content>\n rg stimulated\n GLP<\/jats:styled-content>\n \u20101 and\n PYY<\/jats:styled-content>\n release\n in vitro<\/jats:italic>\n and\n in vivo<\/jats:italic>\n . Pharmacological blockade of\n GLP<\/jats:styled-content>\n \u20101 and\n PYY<\/jats:styled-content>\n receptors did not influence the anorectic effect of\n L\u2010A<\/jats:styled-content>\n rg. L\u2010\n A<\/jats:styled-content>\n rg\u2010mediated\n PYY<\/jats:styled-content>\n release modulated net ion transport across the gut mucosa. Intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) administration of\n L\u2010A<\/jats:styled-content>\n rg suppressed food intake in rats.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n L\u2010A<\/jats:styled-content>\n rg reduced food intake and stimulated gut hormone release in rodents. The anorectic effect of\n L\u2010A<\/jats:styled-content>\n rg is unlikely to be mediated by\n GLP<\/jats:styled-content>\n \u20101 and\n PYY<\/jats:styled-content>\n , does not require\n GPRC6A<\/jats:styled-content>\n signalling and is not mediated via the vagus. I.c.v. and i.p. administration of\n L\u2010A<\/jats:styled-content>\n rg suppressed food intake in rats, suggesting that\n L\u2010A<\/jats:styled-content>\n rg may act on the brain to influence food intake. Further work is required to determine the mechanisms by which\n L\u2010A<\/jats:styled-content>\n rg suppresses food intake and its utility in the treatment of obesity.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12644","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T06:50:16Z","timestamp":1455173416000},"page":"508-518","source":"Crossref","is-referenced-by-count":47,"title":["L<\/scp>\n \u2010arginine promotes gut hormone release and reduces food intake in rodents"],"prefix":"10.1111","volume":"18","author":[{"given":"A.","family":"Alamshah","sequence":"first","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"McGavigan","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Spreckley","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Kinsey\u2010Jones","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Amin","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. R.","family":"Tough","sequence":"additional","affiliation":[{"name":"Wolfson Centre for Age\u2010Related Diseases, Institute of Psychiatry, Psychology and Neuroscience King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"O'Hara","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Moolla","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Banks","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"France","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Hyberg","sequence":"additional","affiliation":[{"name":"AstraZeneca R&D M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Norton","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Cheong","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lehmann","sequence":"additional","affiliation":[{"name":"AstraZeneca R&D M\u00f6lndal Sweden"},{"name":"Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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