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Insulin secretion by \u03b2\u2010cells of the pancreatic islets is tightly coupled to blood glucose concentration and modulated by a large number of blood\u2010borne or locally released mediators, including endocannabinoids. Obesity and its complications, including\n                    <jats:styled-content style=\"fixed-case\">T2D<\/jats:styled-content>\n                    , are associated with increased activity of the endocannabinoid\/\n                    <jats:styled-content style=\"fixed-case\">\n                      CB\n                      <jats:sub>1<\/jats:sub>\n                    <\/jats:styled-content>\n                    receptor (\n                    <jats:styled-content style=\"fixed-case\">\n                      CB\n                      <jats:sub>1<\/jats:sub>\n                      R\n                    <\/jats:styled-content>\n                    ) system, as indicated by the therapeutic effects of\n                    <jats:styled-content style=\"fixed-case\">\n                      CB\n                      <jats:sub>1<\/jats:sub>\n                      R\n                    <\/jats:styled-content>\n                    antagonists. Similar beneficial effects of\n                    <jats:styled-content style=\"fixed-case\">\n                      CB\n                      <jats:sub>1<\/jats:sub>\n                      R\n                    <\/jats:styled-content>\n                    antagonists with limited brain penetrance indicate the important role of\n                    <jats:styled-content style=\"fixed-case\">\n                      CB\n                      <jats:sub>1<\/jats:sub>\n                      R\n                    <\/jats:styled-content>\n                    in peripheral tissues, including the endocrine pancreas. Pancreatic \u03b2\u2010cells express all of the components of the endocannabinoid system, and endocannabinoids modulate their function via both autocrine and paracrine mechanisms, which influence basal and glucose\u2010induced insulin secretion and also affect \u03b2\u2010cell proliferation and survival. The present brief review will survey available information on the modulation of these processes by endocannabinoids and their receptors, with an attempt to assess the contribution of such effects to glycaemic control in\n                    <jats:styled-content style=\"fixed-case\">T2D<\/jats:styled-content>\n                    and insulin resistance.\n                  <\/jats:p>","DOI":"10.1111\/dom.12646","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T04:07:16Z","timestamp":1455595636000},"page":"549-557","source":"Crossref","is-referenced-by-count":54,"title":["Endocannabinoid regulation of\n                    <i>\u03b2<\/i>\n                    \u2010cell functions: implications for glycaemic control and diabetes"],"prefix":"10.1111","volume":"18","author":[{"given":"T.","family":"Jourdan","sequence":"first","affiliation":[{"name":"Laboratory of Physiologic Studies National Institute on Alcohol Abuse and Alcoholism, National Institutes of 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