{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:27:41Z","timestamp":1792099661713,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T00:00:00Z","timestamp":1464652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2016,9]]},"abstract":"\n Aim<\/jats:title>\n \n To conduct a prospective randomized trial to investigate the effect of glucagon\u2010like peptide\u20101 (\n GLP<\/jats:styled-content>\n \u20101) analogues on ectopic fat stores.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 44 obese subjects with type 2 diabetes uncontrolled on oral antidiabetic drugs were randomly assigned to receive exenatide or reference treatment according to French guidelines. Epicardial adipose tissue (\n EAT<\/jats:styled-content>\n ), myocardial triglyceride content (\n MTGC<\/jats:styled-content>\n ), hepatic triglyceride content (\n HTGC<\/jats:styled-content>\n ) and pancreatic triglyceride content (\n PTGC<\/jats:styled-content>\n ) were assessed 45\u2009min after a standardized meal with\n 3T<\/jats:styled-content>\n magnetic resonance imaging and proton magnetic resonance spectroscopy before and after 26\u2009weeks of treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The study population had a mean glycated haemoglobin (\n HbA1c<\/jats:styled-content>\n ) level of 7.5\u2009\u00b1\u20090.2% and a mean body mass index of 36.1\u2009\u00b1\u20091.1\u2009kg\/m\n 2<\/jats:sup>\n . Ninety five\u2009percent had hepatic steatosis at baseline (\n HTGC<\/jats:styled-content>\n \u2009\u2265\u20095.6%). Exenatide and reference treatment led to a similar improvement in\n HbA1c<\/jats:styled-content>\n (\u22120.7\u2009\u00b1\u20090.3% vs. \u22120.7\u2009\u00b1\u20090.4%; p\u2009=\u20090.29), whereas significant weight loss was observed only in the exenatide group (\u22125.5\u2009\u00b1\u20091.2\u2009kg vs. \u22120.2\u2009\u00b1\u20090.8\u2009kg; p\u2009=\u20090.001 for the difference between groups). Exenatide induced a significant reduction in\n EAT<\/jats:styled-content>\n (\u22128.8\u2009\u00b1\u20092.1%) and\n HTGC<\/jats:styled-content>\n (\u221223.8\u2009\u00b1\u20099.5%), compared with the reference treatment (\n EAT<\/jats:styled-content>\n : \u22121.2\u2009\u00b1\u20091.6%, p\u2009=\u20090.003;\n HTGC<\/jats:styled-content>\n : +12.5\u2009\u00b1\u20099.6%, p\u2009=\u20090.007). No significant difference was observed in other ectopic fat stores,\n PTGC<\/jats:styled-content>\n or\n MTGC<\/jats:styled-content>\n . In the group treated with exenatide, reductions in liver fat and\n EAT<\/jats:styled-content>\n were not associated with homeostatic model assessment of insulin resistance index, adiponectin,\n HbA1c<\/jats:styled-content>\n or fructosamin change, but were significantly related to weight loss (r\u2009=\u20090.47, p\u2009=\u20090.03, and r\u2009=\u20090.50, p\u2009=\u20090.018, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our data indicate that exenatide is an effective treatment to reduce liver fat content and epicardial fat in obese patients with type 2 diabetes, and these effects are mainly weight loss dependent.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12680","type":"journal-article","created":{"date-parts":[[2016,4,23]],"date-time":"2016-04-23T04:54:40Z","timestamp":1461387280000},"page":"882-891","source":"Crossref","is-referenced-by-count":243,"title":["Exenatide decreases liver fat content and epicardial adipose tissue in patients with obesity and type 2 diabetes: a prospective randomized clinical trial using magnetic resonance imaging and spectroscopy"],"prefix":"10.1111","volume":"18","author":[{"given":"A.","family":"Dutour","sequence":"first","affiliation":[{"name":"Inserm U1062, Inra U1260, Facult\u00e9 de M\u00e9decine 13385 Marseille France"},{"name":"Aix Marseille Universit\u00e9 Marseille France"},{"name":"Department of Endocrinology Metabolic Diseases and Nutrition, Pole Endo Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Abdesselam","sequence":"additional","affiliation":[{"name":"Inserm U1062, Inra U1260, Facult\u00e9 de M\u00e9decine 13385 Marseille France"},{"name":"Aix Marseille Universit\u00e9 Marseille France"},{"name":"Centre de R\u00e9sonance Magn\u00e9tique Biologique et M\u00e9dicale CNRS UMR 7339 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ancel","sequence":"additional","affiliation":[{"name":"Inserm U1062, Inra U1260, Facult\u00e9 de M\u00e9decine 13385 Marseille France"},{"name":"Aix Marseille Universit\u00e9 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Kober","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9 Marseille France"},{"name":"Centre de R\u00e9sonance Magn\u00e9tique Biologique et M\u00e9dicale CNRS UMR 7339 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mrad","sequence":"additional","affiliation":[{"name":"Inserm U1062, Inra U1260, Facult\u00e9 de M\u00e9decine 13385 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Darmon","sequence":"additional","affiliation":[{"name":"Inserm U1062, Inra U1260, Facult\u00e9 de M\u00e9decine 13385 Marseille France"},{"name":"Aix Marseille Universit\u00e9 Marseille France"},{"name":"Department of Endocrinology Metabolic Diseases and Nutrition, Pole Endo Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Ronsin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Metabolic Diseases and Nutrition, Pole Endo Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Pradel","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9 Marseille France"},{"name":"Statistics Department, Assistance Publique H\u00f4pitaux Marseille CHU Sainte Marguerite Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Lesavre","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9 Marseille France"},{"name":"Centre d'investigation Clinique, 1409, Assistance Publique H\u00f4pitaux de Marseille CHU Nord Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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