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Recently, various histological abnormalities have been reported in human pancreatic tissue from brain\u2010dead organ donors who had been exposed to incretin\u2010based drugs. In the present study we examined pancreatic tissue collected at surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Human pancreatic tissue from 7 type 2\u2010diabetic patients treated with incretin\u2010based drugs (type 2\u2010I), 6 diabetic patients without incretin treatment (type 2\u2010\n                      <jats:styled-content style=\"fixed-case\">NI<\/jats:styled-content>\n                      ), 11 patients without diabetes (no diabetes group) and 9 brain\u2010dead organ donors (\n                      <jats:styled-content style=\"fixed-case\">BDOD<\/jats:styled-content>\n                      group) was examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fractional beta\u2010cell area was reduced in the type 2\u2010\n                      <jats:styled-content style=\"fixed-case\">NI<\/jats:styled-content>\n                      group compared to the group without diabetes (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05), but there was no difference compared to the type 2\u2010I patients. Alpha\u2010cell area (\n                      <jats:italic>P<\/jats:italic>\n                      = .30), beta\u2010cell replication (\n                      <jats:italic>P<\/jats:italic>\n                      = .17) and alpha\u2010cell replication (\n                      <jats:italic>P<\/jats:italic>\n                      = .91) were not different. There were also no differences in acinar cell (\n                      <jats:italic>P<\/jats:italic>\n                      = .13) and duct cell replication (\n                      <jats:italic>P<\/jats:italic>\n                      = .099). Insulin\u2010positive duct cells were more frequent in the type 2\u2010I and the\n                      <jats:styled-content style=\"fixed-case\">BDOD<\/jats:styled-content>\n                      groups (\n                      <jats:italic>P<\/jats:italic>\n                      = .034). No co\u2010expression of insulin and glucagon was detected. Pancreatic intraepithelial neoplasia (\n                      <jats:styled-content style=\"fixed-case\">PanIN<\/jats:styled-content>\n                      ) lesions were very rare, all low\u2010grade (\n                      <jats:styled-content style=\"fixed-case\">PanIN<\/jats:styled-content>\n                      1a and 1b) and tended to occur more frequently in the type 2\u2010I group (\n                      <jats:italic>P<\/jats:italic>\n                      = .084).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present results did not reveal marked histological abnormalities in the pancreas of incretin\u2010treated patients with type 2 diabetes. Low numbers of specimens available and a large inter\u2010individual variability of the findings warrant caution regarding the interpretation of histological data concerning drug effects on the human pancreas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.12766","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T05:17:08Z","timestamp":1471843028000},"page":"1253-1262","source":"Crossref","is-referenced-by-count":16,"title":["Histological changes in endocrine and exocrine pancreatic tissue from patients exposed to incretin\u2010based therapies"],"prefix":"10.1111","volume":"18","author":[{"given":"Sandra","family":"Ueberberg","sequence":"first","affiliation":[{"name":"Diabetes Division, St. Josef\u2010Hospital Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik","family":"J\u00fctte","sequence":"additional","affiliation":[{"name":"Department of Pathology 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