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Cumulative fracture incidence rates were calculated and their association with study treatment assignment was examined using multivariable\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      ox proportional hazards regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The baseline mean (standard deviation) participant age was 65.5 (8.0) years, diabetes duration was 11.6 (8.1) years and glycated haemoglobin level was 7.2 (0.5)% [55.2 (5.5) mmol\/mol], and 29.3% of participants were women and 32.1% were non\u2010white. During 43 222 person\u2010years\u2019 follow\u2010up, 375 (2.6%; 8.7 per 1000 person\u2010years) had a fracture; 146 were major osteoporotic fractures (hip, n = 34; upper extremity, n = 81; and clinical spine, n = 31). Adjusted analyses showed fracture risk increased independently with older age (\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      <\/jats:italic>\n                      &lt; .001), female sex (\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      <\/jats:italic>\n                      &lt; .001), white race (\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      <\/jats:italic>\n                      &lt; .001), lower diastolic blood pressure (\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      <\/jats:italic>\n                      &lt; .001) and diabetic neuropathy (\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      <\/jats:italic>\n                      = .003). Sitagliptin, compared with placebo, was not associated with a higher fracture risk [189 vs 186 incident fractures: unadjusted hazard ratio (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      ) 1.01, 95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ) 0.82 to 1.23,\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      <\/jats:italic>\n                      = .944; adjusted\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      1.03,\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      <\/jats:italic>\n                      = .745], major osteoporotic fractures (\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      <\/jats:italic>\n                      = .673) or hip fractures (\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      <\/jats:italic>\n                      = .761). Insulin therapy was associated with a higher fracture risk (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      1.40, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.02\u20101.91;\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      <\/jats:italic>\n                      = .035), and metformin with a lower risk (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      0.76, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.59\u20100.98;\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      <\/jats:italic>\n                      = .035).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Fractures were common among people with diabetes in the\n                      <jats:styled-content style=\"fixed-case\">TECOS<\/jats:styled-content>\n                      study, but were not related to sitagliptin therapy. Insulin and metformin treatment were associated with higher and lower fracture risks, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.12786","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T09:56:50Z","timestamp":1473328610000},"page":"78-86","source":"Crossref","is-referenced-by-count":59,"title":["Sitagliptin and risk of fractures in type 2 diabetes:\n                    <scp>R<\/scp>\n                    esults from the\n                    <scp>TECOS<\/scp>\n                    trial"],"prefix":"10.1111","volume":"19","author":[{"given":"Robert G.","family":"Josse","sequence":"first","affiliation":[{"name":"St. Michael's Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit R.","family":"Majumdar","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinggan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Canadian VIGOUR Centre University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Adler","sequence":"additional","affiliation":[{"name":"Wolfson Diabetes and Endocrine Clinic, Addenbrooke's Hospital Cambridge University Hospitals Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Angelyn","family":"Bethel","sequence":"additional","affiliation":[{"name":"Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Buse","sequence":"additional","affiliation":[{"name":"University of North Carolina School of Medicine  Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer B.","family":"Green","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith D.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc.  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