{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:18:00Z","timestamp":1789103880354,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010710","name":"Dairy Farmers of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010710","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Genomic Research and Development Initiative Program"},{"DOI":"10.13039\/100011094","name":"Public Health Agency of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011094","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,1]]},"abstract":"\n Aims<\/jats:title>\n \n Low serum 25\u2010hydroxyvitamin\u2010D (25(\n OH<\/jats:styled-content>\n )D) concentrations are associated with insulin resistance, \u03b2\u2010cell dysfunction and type 2 diabetes. We conducted a 24\u2010week double\u2010blind, randomized, placebo\u2010controlled trial to examine the effect of 28 000\n IU<\/jats:styled-content>\n of vitamin\n \n D\n 3<\/jats:sub>\n <\/jats:styled-content>\n once weekly on plasma glucose after a 2 hour\u201075 g oral glucose tolerance test (\n 2hrPC<\/jats:styled-content>\n glucose), insulin sensitivity and \u03b2\u2010cell function.\n <\/jats:p>\n <\/jats:sec>\n \n Study Design and Methods<\/jats:title>\n \n A total of 71 participants with serum 25(\n OH<\/jats:styled-content>\n )D \u226465 nmol\/L, impaired fasting glucose and elevated glycated hemoglobin were randomly assigned to receive 28 000\n IU<\/jats:styled-content>\n of vitamin\n \n D\n 3<\/jats:sub>\n <\/jats:styled-content>\n (\n VitD<\/jats:styled-content>\n ; n = 35) or placebo (n = 36) in cheese once weekly for 24 weeks. The primary outcome was the change in\n 2hPC<\/jats:styled-content>\n glucose. Secondary outcomes were fasting glucose, fasting and postprandial insulin, indices of insulin sensitivity and \u03b2\u2013cell function, glycated hemoglobin and lipid profile. Participants underwent an oral glucose tolerance test to determine\n 2hPC<\/jats:styled-content>\n glucose.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean baseline serum 25(\n OH<\/jats:styled-content>\n )D was 48.1 and 47.6 nmol\/L in the\n VitD<\/jats:styled-content>\n and placebo groups, respectively. Serum 25(\n OH<\/jats:styled-content>\n )D significantly increased to 98.7 nmol\/L (51 nmol\/L increase;\n \n P<\/jats:italic>\n <\/jats:styled-content>\n < .0001) in the\n VitD<\/jats:styled-content>\n group. No significant differences in fasting (\n \n P<\/jats:italic>\n <\/jats:styled-content>\n = .42) or\n 2hPC<\/jats:styled-content>\n glucose (\n \n P<\/jats:italic>\n <\/jats:styled-content>\n = .55) or other indices of glucose metabolism, including \u03b2\u2010cell function and insulin sensitivity, were observed between groups. A subgroup analysis of individuals with 25(\n OH<\/jats:styled-content>\n )D < 50 nmol\/L and prediabetes did not change these results. The\n VitD<\/jats:styled-content>\n group exhibited a significant reduction in\n LDL<\/jats:styled-content>\n cholesterol (\u22120.27 vs 0.01 mmol\/L,\n \n P<\/jats:italic>\n <\/jats:styled-content>\n = .03).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Weekly doses of vitamin\n \n D\n 3<\/jats:sub>\n <\/jats:styled-content>\n in individuals with suboptimal vitamin D levels who were at risk for type 2 diabetes did not improve oral glucose tolerance or markers of glycaemic status.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12794","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T11:00:33Z","timestamp":1474887633000},"page":"133-141","source":"Crossref","is-referenced-by-count":69,"title":["Effect of vitamin D supplementation on oral glucose tolerance in individuals with low vitamin D status and increased risk for developing type 2 diabetes (\n EVIDENCE<\/scp>\n ): A double\u2010blind, randomized, placebo\u2010controlled clinical trial"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6980-4347","authenticated-orcid":false,"given":"Tracy S.","family":"Moreira\u2010Lucas","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Human Health and Nutritional Sciences University of Guelph Guelph Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Rabasa\u2010Lhoret","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al & Nutrition Department Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold","family":"Vieth","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison L.","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Department of Statistical Sciences University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Badawi","sequence":"additional","affiliation":[{"name":"Public Health Risk Science Division Public Health Agency of Canada Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M. 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