{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T05:51:15Z","timestamp":1791697875548,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T00:00:00Z","timestamp":1479081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001734","name":"University of Copenhagen","doi-asserted-by":"crossref","award":["211-0649\/11-3012"],"award-info":[{"award-number":["211-0649\/11-3012"]}],"id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Copenhagen\/Mental Health Services, Capital Region of Denmark","award":["R25-A2701"],"award-info":[{"award-number":["R25-A2701"]}]},{"name":"Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS","award":["R25-A2701"],"award-info":[{"award-number":["R25-A2701"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Schizophrenia is associated with cardiovascular co\u2010morbidity and a reduced life\u2010expectancy of up to 20 years. Antipsychotics are dopamine\n                      <jats:styled-content style=\"fixed-case\">\n                        D\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:styled-content>\n                      receptor antagonists and are the standard of medical care in schizophrenia, but the drugs are associated with severe metabolic side effects such as obesity and diabetes. Glucagon\u2010like peptide\u20101 receptor agonists (\n                      <jats:styled-content style=\"fixed-case\">GLP\u20101RAs<\/jats:styled-content>\n                      ) are registered for treatment of both obesity and type 2 diabetes. We investigated metabolic effects of the\n                      <jats:styled-content style=\"fixed-case\">GLP\u20101RA<\/jats:styled-content>\n                      , exenatide once\u2010weekly, in non\u2010diabetic, antipsychotic\u2010treated, obese patients with schizophrenia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>Antipsychotic\u2010treated, obese, non\u2010diabetic, schizophrenia spectrum patients were randomized to double\u2010blinded adjunctive treatment with once\u2010weekly subcutaneous exenatide (n = 23) or placebo (n = 22) injections for 3 months. The primary outcome was loss of body weight after treatment and repeated measures analysis of variance was used as statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between March 2013 and June 2015, 40 patients completed the trial. At baseline, mean body weight was 118.3 \u00b1 16.0 kg in the exenatide group and 111.7 \u00b1 18.0 kg in the placebo group, with no group differences (\n                      <jats:italic>P<\/jats:italic>\n                      = .23). The exenatide and placebo groups experienced significant (\n                      <jats:italic>P<\/jats:italic>\n                      = .004), however similar (\n                      <jats:italic>P<\/jats:italic>\n                      = .98), weight losses of 2.24 \u00b1 3.3 and 2.23 \u00b1 4.4 kg, respectively, after 3 months of treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Treatment with exenatide once\u2010weekly did not promote weight loss in obese, antipsychotic\u2010treated patients with schizophrenia compared to placebo. Our results could suggest that the body weight\u2010lowering effect of\n                      <jats:styled-content style=\"fixed-case\">GLP\u20101RAs<\/jats:styled-content>\n                      involves dopaminergic signaling, but blockade of other receptor systems may also play a role. Nevertheless, anti\u2010obesity regimens effective in the general population may not be readily implemented in antipsychotic\u2010treated patients with schizophrenia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.12795","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T11:00:41Z","timestamp":1474887641000},"page":"162-171","source":"Crossref","is-referenced-by-count":100,"title":["Effect of\n                    <scp>GLP<\/scp>\n                    \u20101 receptor agonist treatment on body weight in obese antipsychotic\u2010treated patients with schizophrenia:\n                    <scp>a<\/scp>\n                    randomized, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"19","author":[{"given":"Pelle L.","family":"Ish\u00f8y","sequence":"first","affiliation":[{"name":"Center for Neuropsychiatric Schizophrenia Research, CNSR, and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Centre Glostrup University of Copenhagen  Glostrup Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen, Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip K.","family":"Knop","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen, Copenhagen  Denmark"},{"name":"Center for Diabetes Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"The Novo Nordisk Foundation Centre for Basic Metabolic Research, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian V.","family":"Broberg","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Schizophrenia Research, CNSR, and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Centre Glostrup University of Copenhagen  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaj","family":"Bak","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Schizophrenia Research, CNSR, and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Centre Glostrup University of Copenhagen  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik B.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET, Rigshospitalet University of Copenhagen  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas R.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Research Center for Ageing and Osteoporosis, Departments of Clinical Biochemistry and Medicine, Rigshospitalet University of Copenhagen  Glostrup Denmark"},{"name":"OPEN, Odense Patient Data Explorative Network, Odense University Hospital\/Institute of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens J.","family":"Holst","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Centre for Basic Metabolic Research, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birte Y.","family":"Glenth\u00f8j","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Schizophrenia Research, CNSR, and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Centre Glostrup University of Copenhagen  Glostrup Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen, Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn H.","family":"Ebdrup","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Schizophrenia Research, CNSR, and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Centre Glostrup University of Copenhagen  Glostrup 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