{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:41:21Z","timestamp":1790106081479,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T00:00:00Z","timestamp":1481155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondation Leducq Grant","award":["13CVD03"],"award-info":[{"award-number":["13CVD03"]}]},{"name":"Fundazione CARIPLO"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,3]]},"abstract":"\n Pro\u2010protein convertase subtilisin\/kexin type 9 (\n PCSK9<\/jats:styled-content>\n ) is a critical regulator of\n LDL<\/jats:styled-content>\n cholesterol metabolism. Little is known, however, about the regulation of\n PCSK9<\/jats:styled-content>\n in patients with type 1 diabetes (\n T1D<\/jats:styled-content>\n ). In the present study, we aimed to determine the relationship between circulating\n PCSK9<\/jats:styled-content>\n and metabolic variables in\n T1D<\/jats:styled-content>\n . Plasma\n PCSK9<\/jats:styled-content>\n levels were measured in 195 people with\n T1D<\/jats:styled-content>\n (mean age 38.8 years, mean diabetes duration 17.2 years, mean glycated haemoglobin [\n HbA1c<\/jats:styled-content>\n ] 8.3%), who were free of any lipid\u2010lowering agent. Plasma\n PCSK9<\/jats:styled-content>\n was positively correlated with\n LDL<\/jats:styled-content>\n cholesterol (\n P<\/jats:italic>\n = .0007), triglycerides (\n P<\/jats:italic>\n = .004), apolipoprotein B (\n P<\/jats:italic>\n = .005),\n HbA1c<\/jats:styled-content>\n (\n P<\/jats:italic>\n = .003), systolic (\n P<\/jats:italic>\n = .003) and diastolic (\n P<\/jats:italic>\n = .001) blood pressure and body mass index (0.02). In multivariate analysis,\n PCSK9<\/jats:styled-content>\n concentration was independently associated with\n HbA1c<\/jats:styled-content>\n (\n P<\/jats:italic>\n = .02) and\n LDL<\/jats:styled-content>\n cholesterol (\n P<\/jats:italic>\n = .03). After classifying patients according to\n HbA1c<\/jats:styled-content>\n tertile, the correlation between\n PCSK9<\/jats:styled-content>\n and\n LDL<\/jats:styled-content>\n cholesterol was only observed in the highest tertile (\n P<\/jats:italic>\n = .0006; Rho = 0.43), whereas no correlation was found in the lowest and intermediate tertiles. This study suggests that good glycaemic control abolishes the positive relationship between\n PCSK9<\/jats:styled-content>\n and\n LDL<\/jats:styled-content>\n cholesterol in patients with\n T1D<\/jats:styled-content>\n ; however, the underlying molecular mechanisms remain to be established.\n <\/jats:p>","DOI":"10.1111\/dom.12819","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T23:56:42Z","timestamp":1481241402000},"page":"448-451","source":"Crossref","is-referenced-by-count":19,"title":["Glycaemic control influences the relationship between plasma\n PCSK9<\/scp>\n and\n LDL<\/scp>\n cholesterol in type 1 diabetes"],"prefix":"10.1111","volume":"19","author":[{"given":"St\u00e9phanie","family":"Laugier\u2010Robiolle","sequence":"first","affiliation":[{"name":"Endocrinology \u2010 Diabetology and CIC1402, CHU Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Verg\u00e8s","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, INSERM CRI 866, CHU Dijon Universit\u00e9 Bourgogne Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00eblle","family":"Le Bras","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, l'Institut du Thorax, CHU Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Gand","sequence":"additional","affiliation":[{"name":"Endocrinology \u2010 Diabetology and CIC1402, CHU Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bouillet","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, INSERM CRI 866, CHU Dijon Universit\u00e9 Bourgogne Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Jean","family":"Saulnier","sequence":"additional","affiliation":[{"name":"INSERM, CIC1402 Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Le May","sequence":"additional","affiliation":[{"name":"l'Institut du Thorax, INSERM, CNRS Nantes University Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Pichelin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, l'Institut du Thorax, INSERM, CNRS, CHU Nantes Nantes University Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Mar\u00e9chaud","sequence":"additional","affiliation":[{"name":"Endocrinology \u2010 Diabetology and CIC1402, CHU Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Michel","family":"Petit","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, INSERM CRI 866, CHU Dijon Universit\u00e9 Bourgogne Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samy","family":"Hadjadj","sequence":"additional","affiliation":[{"name":"Endocrinology \u2010 Diabetology and CIC1402, CHU Poitiers Poitiers France"},{"name":"INSERM, CIC1402 Poitiers France"},{"name":"UFR M\u00e9decine Pharmacie University of Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Cariou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, l'Institut du Thorax, INSERM, CNRS, CHU Nantes Nantes University Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.04.018"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1161"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv174"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000034"},{"key":"e_1_2_6_7_1","first-page":"2000","volume-title":"Endotext [Internet]","author":"Feingold K","year":"2000"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508582200"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2007.11.009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305688"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.04.015"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0141"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2712"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2015.03.003"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06495.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.07.098"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052187"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:37:51Z","timestamp":1761871071000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,8]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/dom.12819"],"URL":"https:\/\/doi.org\/10.1111\/dom.12819","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,8]]}}}