{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:00:30Z","timestamp":1772748030322,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T00:00:00Z","timestamp":1481500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Philips\/Respironics"},{"name":"Diabetes Research and Training Center at the University of Chicago"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P01 AG11412"],"award-info":[{"award-number":["P01 AG11412"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["CTSA UL1 RR024999"],"award-info":[{"award-number":["CTSA UL1 RR024999"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 HL119161"],"award-info":[{"award-number":["R01 HL119161"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,3]]},"abstract":"\n Studies examining the impact of\n CPAP<\/jats:styled-content>\n treatment on glycaemic control have yielded conflicting results, partly because of insufficient nightly CPAP use. We examined the 24\u2010hour profiles of glucose, insulin and counter\u2010regulatory hormones in 12 subjects with type 2 diabetes and\n OSA<\/jats:styled-content>\n before and after 1 week of effective in\u2010laboratory\n CPAP<\/jats:styled-content>\n therapy over an entire 8\u2010hour night thus ensuring optimal CPAP compliance. Blood samples were collected every 15 to 30 minutes for 24 hours under controlled conditions. The 24\u2010hour mean glucose decreased from 153.2 \u00b1 33.0 to 139.7 \u00b1 24.2 mg\/\n dL<\/jats:styled-content>\n with\n CPAP<\/jats:styled-content>\n (\u221213.5 \u00b1 13.5 mg\/\n dL<\/jats:styled-content>\n ;\n P<\/jats:italic>\n = .005) without change in insulin levels. Morning fasting glucose levels decreased by 14.6 \u00b1 3 mg\/dL (\n P<\/jats:italic>\n = .001) and the dawn phenomenon decreased by 7.8 \u00b1 9.8 mg\/\n dL<\/jats:styled-content>\n (\n P<\/jats:italic>\n = .019).\n CPAP<\/jats:styled-content>\n treatment decreased norepinephrine levels while the 24\u2010hour profiles of growth hormone and cortisol remained unchanged. In conclusion, 1 week of effective treatment of\n OSA<\/jats:styled-content>\n over an entire 8\u2010hour night results in a clinically significant improvement in glycaemic control via an amelioration of evening fasting glucose metabolism and a reduction in the dawn phenomenon, a late\u2010night glucose increase that is not adequately treated by oral medications.\n <\/jats:p>\n \n Clinical Trials Information<\/jats:bold>\n :\n ClinicalTrials.gov<\/jats:ext-link>\n Identifier: NCT01136785.\n <\/jats:p>","DOI":"10.1111\/dom.12823","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T06:57:17Z","timestamp":1479365837000},"page":"452-456","source":"Crossref","is-referenced-by-count":54,"title":["Effect of one week of\n CPAP<\/scp>\n treatment of obstructive sleep apnoea on 24\u2010hour profiles of glucose, insulin and counter\u2010regulatory hormones in type 2 diabetes"],"prefix":"10.1111","volume":"19","author":[{"given":"Babak","family":"Mokhlesi","sequence":"first","affiliation":[{"name":"Section of Pulmonary and Critical Care, Department of Medicine, Sleep Disorders Center University of Chicago Chicago Illinois"},{"name":"Department of Medicine, Sleep, Metabolism and Health Center University of Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Grimaldi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sleep, Metabolism and Health Center University of Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guglielmo","family":"Beccuti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sleep, Metabolism and Health Center University of Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve","family":"Van Cauter","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sleep, Metabolism and Health Center University of Chicago Chicago Illinois"},{"name":"Section of Endocrinology, Diabetes and Metabolism, Department of Medicine University of Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2015.10.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0933"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200909-1423OC"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-2403"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.074351"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201511-2260OC"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201602-0396LE"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201510-1942OC"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2127"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0385"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2088"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201408-1564OC"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200905-0773OC"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118235"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12823","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:37:45Z","timestamp":1761871065000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,12]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/dom.12823"],"URL":"https:\/\/doi.org\/10.1111\/dom.12823","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,12]]}}}