{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:12:03Z","timestamp":1790953923527,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T00:00:00Z","timestamp":1484006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,3]]},"abstract":"\n Aims<\/jats:title>\n To investigate the effect of exenatide on glucose disposal, insulin secretion, \u00df\u2010cell function, lipolysis and hormone concentrations in non\u2010diabetic, morbidly obese subjects under physiological conditions.<\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n Patients were assigned to exenatide 10 \u00b5g twice daily (\n EXE<\/jats:styled-content>\n , n = 15) or control (\n CT<\/jats:styled-content>\n , n = 15) for 3 months. Patients received a meal test\/tracer study (\n MTT<\/jats:styled-content>\n ) to measure endogenous glucose production (\n EGP<\/jats:styled-content>\n ), rate of oral glucose appearance (\n RaO<\/jats:styled-content>\n ), insulin secretion rate (\n ISR<\/jats:styled-content>\n ), \u00df\u2010cell function, hepatic insulin resistance (\n HIR<\/jats:styled-content>\n ) and adipose tissue insulin resistance (\n AT\u2010IR<\/jats:styled-content>\n ) and insulin sensitivity (\n IS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Post treatment, the\n EXE<\/jats:styled-content>\n group showed a significant reduction in body weight (\n P<\/jats:italic>\n < .001). The postmeal time\u2010course of glucose, insulin and\n ISR<\/jats:styled-content>\n showed a lower peak between 60 and 180 minutes in phase with a reduction in\n RaO<\/jats:styled-content>\n (\n P<\/jats:italic>\n < .01). After an initial similar suppression,\n EGP<\/jats:styled-content>\n resumed at higher rates between 60 and 180 minutes (\n P<\/jats:italic>\n = .02) in\n EXE<\/jats:styled-content>\n vs\n CT<\/jats:styled-content>\n , while total\n RaO<\/jats:styled-content>\n and\n EGP<\/jats:styled-content>\n were similar throughout the\n MTT<\/jats:styled-content>\n . In\n EXE<\/jats:styled-content>\n , the postmeal glucagon,\n GLP1<\/jats:styled-content>\n and\n GIP<\/jats:styled-content>\n responses were reduced (\n P<\/jats:italic>\n < .05). Fasting and postprandial lipolysis and \u00df\u2010cell function were unaltered by active treatment.\n HIR<\/jats:styled-content>\n ,\n AT\u2010IR<\/jats:styled-content>\n and\n IS<\/jats:styled-content>\n were all improved after exenatide treatment (\n P<\/jats:italic>\n < .05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In morbidly obese non\u2010diabetic subjects, exenatide causes weight loss, decreased postprandial glycaemia and glucagon response without changes in \u00df\u2010cell function. These effects are consequent upon delayed oral glucose appearance in the circulation. Exenatide treatment is also associated with an improvement in hepatic, adipose tissue and whole\u2010body\n IS<\/jats:styled-content>\n with no influence on postprandial lipolysis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12836","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T10:36:49Z","timestamp":1480415809000},"page":"412-420","source":"Crossref","is-referenced-by-count":25,"title":["Effect of exenatide on postprandial glucose fluxes, lipolysis, and \u00df\u2010cell function in non\u2010diabetic, morbidly obese patients"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9015-7244","authenticated-orcid":false,"given":"Stefania","family":"Camastra","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenno","family":"Astiarraga","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tura","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences, C.N.R. 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