{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T19:00:59Z","timestamp":1772910059741,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T00:00:00Z","timestamp":1484784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>\n                    We investigated the short\u2010term effect of adding liraglutide 1.8\u2009mg once daily to insulin treatment on cardiovascular risk factors in patients with type 1 diabetes. In total, 100 overweight (\n                    <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                    \u226525\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) adult patients (age \u226518\u2009years) with type 1 diabetes and\n                    <jats:styled-content style=\"fixed-case\">HbA1c<\/jats:styled-content>\n                    \u2009\u2265\u20098% (64\u2009mmol\/mol) were randomized to liraglutide 1.8\u2009mg or placebo added to insulin treatment in a 24\u2010week double\u2010blinded, placebo\u2010controlled trial. At baseline and after 24\u2009weeks of treatment, 24\u2010hour blood pressure and heart rate, pulse pressure, pulse wave velocity and carotid intima\u2010media thickness were evaluated. Compared with placebo, liraglutide increased 24\u2010hour heart rate by 4.6 beats per minute (\n                    <jats:styled-content style=\"fixed-case\">BPM<\/jats:styled-content>\n                    );\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2009=\u2009.0015, daytime heart rate by 3.7;\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2009=\u2009.0240 and night\u2010time heart rate by 7.5\n                    <jats:styled-content style=\"fixed-case\">BPM<\/jats:styled-content>\n                    ;\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2009&lt;\u2009.001 after 24\u2009weeks. Diastolic nocturnal blood pressure increased by 4\u2009\n                    <jats:styled-content style=\"fixed-case\">mm Hg<\/jats:styled-content>\n                    ;\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2009=\u2009.0362 in the liraglutide group compared with placebo. In conclusion, in patients with long\u2010standing type 1 diabetes, liraglutide as add\u2010on to insulin increased heart rate and did not improve other cardiovascular risk factors after 24\u2009weeks of treatment.\n                  <\/jats:p>","DOI":"10.1111\/dom.12841","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T08:24:48Z","timestamp":1481271888000},"page":"734-738","source":"Crossref","is-referenced-by-count":22,"title":["Effects of liraglutide on cardiovascular risk factors in patients with type 1 diabetes"],"prefix":"10.1111","volume":"19","author":[{"given":"Thomas F.","family":"Dejgaard","sequence":"first","affiliation":[{"name":"Steno Diabetes Center University of Copenhagen  Gentofte Denmark"},{"name":"Department of Endocrinology, Hvidovre Hospital University of Copenhagen  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanna B.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center University of Copenhagen  Gentofte Denmark"},{"name":"Danish Diabetes Academy  Odense Denmark"},{"name":"Research Centre for Prevention and Health  Capital Region of Denmark, Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian S.","family":"Frandsen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hvidovre Hospital University of Copenhagen  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Asmar","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise","family":"Tarnow","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Nordsj\u00e6llands Hospital Hiller\u00f8d 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