{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:52:51Z","timestamp":1790268771652,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008017","name":"Flinders Medical Centre Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008017","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,4]]},"abstract":"\n Aim<\/jats:title>\n Prednisolone causes hyperglycaemia predominantly between midday and midnight. Consequently, glargine\u2010based basal\u2010bolus insulin regimens may under treat daytime hyperglycaemia and cause nocturnal hypoglycaemia. We investigated whether an isophane\u2010based insulin regimen is safer and more effective than a glargine\u2010based regimen in hospitalized patients.<\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n Fifty inpatients prescribed \u226520 mg\/day prednisolone acutely with (1) finger prick blood glucose level (BGL) \u226515 mmol\/L or (2) BGLs \u226510 mmol\/L within the previous 24 hours were randomized to either insulin isophane or glargine before breakfast and insulin aspart before meals. The initial daily insulin dose was 0.5\u2009\n U<\/jats:styled-content>\n \/kg bodyweight or 130% of the current daily insulin dose. Glycaemic control was assessed using a continuous glucose monitoring system.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n On\n D<\/jats:styled-content>\n ay 1, there were no significant differences in percentage of time outside a target glucose range of 4 to 10\u2009mmol\/\n L<\/jats:styled-content>\n (41.3%\u2009\u00b1\u20095.5% vs 50.0%\u2009\u00b1\u20095.7%,\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009=\u2009.28), mean daily glucose (10.2\u2009\u00b1\u20090.7 vs 10.8\u2009\u00b1\u20090.8\u2009mmol\/\n L<\/jats:styled-content>\n ,\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009=\u2009.57) or glucose <4\u2009mmol\/\n L<\/jats:styled-content>\n (2.2%\u2009\u00b1\u20091.1% vs 2.0%\u2009\u00b1\u20091.3%,\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009=\u2009.92) in patients randomized to isophane and glargine. In patients treated for 3\u2009days, the prednisolone dose was reduced (\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009=\u2009.02) and the insulin dose was increased over time (\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009=\u2009.02), but the percentage of time outside the 4 to 10\u2009mmol\/\n L<\/jats:styled-content>\n glucose range did not differ over time (\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009=\u2009.45) or between groups (\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009=\u2009.24).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n There were no differences in the efficacy or safety of the isophane and glargine\u2010based insulin regimens. We recommend an initial daily insulin dose of 0.5\u2009units\/kg bodyweight if not on insulin, a greater than 30% increase in pre\u2010prednisolone insulin dose and larger insulin dose adjustments in patients with prednisolone\u2010induced hyperglycaemia.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12859","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T03:52:48Z","timestamp":1482205968000},"page":"571-578","source":"Crossref","is-referenced-by-count":36,"title":["Treatment of prednisolone\u2010induced hyperglycaemia in hospitalized patients:\n I<\/scp>\n nsights from a randomized, controlled study"],"prefix":"10.1111","volume":"19","author":[{"given":"Anjana","family":"Radhakutty","sequence":"first","affiliation":[{"name":"School of Medicine Flinders University Adelaide Australia"},{"name":"Southern Adelaide Diabetes and Endocrine Services Repatriation General Hospital Adelaide Australia"},{"name":"Department of Diabetes and Endocrinology Lyell Mc Ewin Hospital Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Stranks","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Lyell Mc Ewin Hospital Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda L.","family":"Mangelsdorf","sequence":"additional","affiliation":[{"name":"Southern Adelaide Diabetes and Endocrine Services Repatriation General Hospital Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie M.","family":"Drake","sequence":"additional","affiliation":[{"name":"Southern Adelaide Diabetes and Endocrine Services Repatriation General Hospital Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Pharmacy Department Flinders Medical Centre Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony T.","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Lyell Mc Ewin Hospital Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen N.","family":"Stranks","sequence":"additional","affiliation":[{"name":"Southern Adelaide Diabetes and Endocrine Services Repatriation General Hospital Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Campbell H.","family":"Thompson","sequence":"additional","affiliation":[{"name":"School of Medicine Flinders University Adelaide Australia"},{"name":"Discipline of Medicine University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6468-7727","authenticated-orcid":false,"given":"Morton G.","family":"Burt","sequence":"additional","affiliation":[{"name":"School of Medicine 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