{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:59:31Z","timestamp":1790395171783,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T00:00:00Z","timestamp":1486425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001424","name":"American Liver Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001424","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005754","name":"Sahlgrenska Universitetssjukhuset","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,4]]},"abstract":"\n Aims<\/jats:title>\n \n To investigate the metabolic effects of 12\u2010week oral supplementation with\n \n L<\/jats:styled-content>\n actobacillus reuteri\n <\/jats:italic>\n DSM<\/jats:styled-content>\n 17938 in patients with type 2 diabetes on insulin therapy.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n In a double\u2010blind trial, we randomized 46 people with type 2 diabetes to placebo or a low (10\n 8<\/jats:sup>\n \u2009\n CFU<\/jats:styled-content>\n \/d) or high dose (10\n 10<\/jats:sup>\n \u2009\n CFU<\/jats:styled-content>\n \/d) of\n \n L<\/jats:styled-content>\n . reuteri\n <\/jats:italic>\n DSM<\/jats:styled-content>\n 17938 for 12\u2009weeks. The primary endpoint was the effect of supplementation on glycated haemoglobin (\n HbA1c<\/jats:styled-content>\n ). Secondary endpoints were insulin sensitivity (assessed by glucose clamp), liver fat content, body composition, body fat distribution, faecal microbiota composition and serum bile acids.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Supplementation with\n \n L<\/jats:styled-content>\n . reuteri\n <\/jats:italic>\n DSM<\/jats:styled-content>\n 17938 for 12\u2009weeks did not affect\n HbA1c<\/jats:styled-content>\n , liver steatosis, adiposity or microbiota composition. Participants who received the highest dose of\n \n L<\/jats:styled-content>\n . reuteri\n <\/jats:italic>\n exhibited increases in insulin sensitivity index (\n ISI<\/jats:styled-content>\n ) and serum levels of the secondary bile acid deoxycholic acid (\n DCA<\/jats:styled-content>\n ) compared with baseline, but these differences were not significant in the between\u2010group analyses.\n Post hoc<\/jats:italic>\n analysis showed that participants who responded with increased\n ISI<\/jats:styled-content>\n after\n \n L<\/jats:styled-content>\n . reuteri\n <\/jats:italic>\n supplementation had higher microbial diversity at baseline, and increased serum levels of\n DCA<\/jats:styled-content>\n after supplementation. In addition, increases in\n DCA<\/jats:styled-content>\n levels correlated with improvement in insulin sensitivity in the probiotic recipients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Intake of\n \n L<\/jats:styled-content>\n . reuteri\n <\/jats:italic>\n DSM<\/jats:styled-content>\n 17938 for 12\u2009weeks did not affect\n HbA1c<\/jats:styled-content>\n in people with type 2 diabetes on insulin therapy; however,\n \n L<\/jats:styled-content>\n . reuteri\n <\/jats:italic>\n improved insulin sensitivity in a subset of participants and we propose that high diversity of the gut microbiota at baseline may be important.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12861","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T21:20:36Z","timestamp":1482614436000},"page":"579-589","source":"Crossref","is-referenced-by-count":244,"title":["Metabolic effects of\n \n L<\/scp>\n actobacillus reuteri\n <\/i>\n DSM<\/scp>\n 17938 in people with type 2 diabetes:\n A<\/scp>\n randomized controlled trial"],"prefix":"10.1111","volume":"19","author":[{"given":"Reza","family":"Mobini","sequence":"first","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine Institute of Medicine, University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Tremaroli","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine Institute of Medicine, University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"St\u00e5hlman","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine Institute of Medicine, University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Department of Biology and Biological Engineering Chalmers University of Technology Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Levin","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine Institute of Medicine, University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ljungberg","sequence":"additional","affiliation":[{"name":"Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Sohlin","sequence":"additional","affiliation":[{"name":"Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hel\u00e9ne","family":"Bert\u00e9us Forslund","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Perkins","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine Institute of Medicine, University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"B\u00e4ckhed","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine Institute of Medicine, University of Gothenburg Gothenburg Sweden"},{"name":"Novo Nordisk Foundation Centre for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4032-3317","authenticated-orcid":false,"given":"Per\u2010Anders","family":"Jansson","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine Institute of Medicine, University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,7]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Robbins and Cotran Pathologic Basis of Disease","author":"Kumar V","year":"2015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0413"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2014.944160"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.66"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034938"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.115.010587"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004088"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2016.06.014"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201600240"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12198"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08821"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R500013-JLR200"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043910"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/51.6.1106"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1600732"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-0233\/20\/10\/104035"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1979.237.3.E214"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.021"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2011.08.013"},{"issue":"6","key":"e_1_2_6_21_1","first-page":"531","article-title":"Effects of probiotic yogurt consumption on lipid profile in type 2 diabetic patients: a randomized controlled clinical trial","volume":"19","author":"Mohamadshahi M","year":"2014","journal-title":"J Res Med Sci"},{"issue":"2","key":"e_1_2_6_22_1","first-page":"228","article-title":"Effect of probiotic fermented milk (kefir) on glycemic control and lipid profile in type 2 diabetic patients: a randomized double\u2010blind placebo\u2010controlled clinical trial","volume":"44","author":"Ostadrahimi A","year":"2015","journal-title":"Iran J Public Health"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.11.011"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0554"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2690"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510002874"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.153"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2013.28"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2209-c2"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07540"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12506"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16504"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.305789"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0639"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0030"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-011-0187-x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.08.001"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2004.tb03526.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15766"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:44:51Z","timestamp":1761893091000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,7]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/dom.12861"],"URL":"https:\/\/doi.org\/10.1111\/dom.12861","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,7]]}}}