{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T19:53:41Z","timestamp":1785786821449,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Novo Nordisk A\/S, Bagsvaerd, Denmark"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,6]]},"abstract":"\n We assessed the effects of liraglutide treatment on five cardiovascular risk biomarkers, reflecting different pathophysiology: tumour necrosis factor (\n TNF<\/jats:styled-content>\n )\u2010\u03b1; soluble urokinase plasminogen activator receptor (\n suPAR<\/jats:styled-content>\n ); mid\u2010regional pro\u2010adrenomedullin (\n MR\u2010proADM<\/jats:styled-content>\n ); mid\u2010regional pro\u2010atrial natriuretic peptide (\n MR\u2010proANP<\/jats:styled-content>\n ); and copeptin, in people with type 2 diabetes with albuminuria. In a randomized, double\u2010blind, placebo\u2010controlled, crossover trial we enrolled people with type 2 diabetes and persistent albuminuria (urinary albumin\u2010to\u2010creatinine ratio [\n UACR<\/jats:styled-content>\n ] >30\u2009mg\/g) and estimated glomerular filtration rate (\n eGFR<\/jats:styled-content>\n ) \u226530\u2009\n mL<\/jats:styled-content>\n \/min\/1.73\u2009m\n 2<\/jats:sup>\n . Participants received liraglutide (1.8\u2009mg\/d) and matched placebo for 12\u2009weeks, in random order. The primary endpoint was change in albuminuria; this was a prespecified sub\u2010study. A total of 32 participants were randomized, of whom 27 completed the study.\n TNF<\/jats:styled-content>\n \u2010\u03b1 level was 12% (95% confidence interval [\n CI<\/jats:styled-content>\n ] 3; 20) lower after liraglutide treatment compared with placebo (\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009=\u2009.012);\n MR\u2010proADM<\/jats:styled-content>\n level was 4% (95%\n CI<\/jats:styled-content>\n 0; 8) lower after liraglutide treatment compared with placebo (\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009=\u2009.038), and\n MR\u2010proANP<\/jats:styled-content>\n level was 13% (95%\n CI<\/jats:styled-content>\n 4; 21) lower after liraglutide treatment compared with placebo (\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009=\u2009.006). In the present study, we showed anti\u2010inflammatory effects of liraglutide treatment, reflected in reductions in levels of\n TNF<\/jats:styled-content>\n \u2010\u03b1 and\n MR\u2010proADM<\/jats:styled-content>\n , while the reduction in\n MR\u2010proANP<\/jats:styled-content>\n levels may represent a clinically relevant benefit with regard to heart failure.\n <\/jats:p>","DOI":"10.1111\/dom.12884","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T04:20:02Z","timestamp":1484886002000},"page":"901-905","source":"Crossref","is-referenced-by-count":57,"title":["Effects of liraglutide on cardiovascular risk biomarkers in patients with type 2 diabetes and albuminuria:\n A<\/scp>\n sub\u2010analysis of a randomized, placebo\u2010controlled, double\u2010blind, crossover trial"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1489-0636","authenticated-orcid":false,"given":"Bernt Johan","family":"von Scholten","sequence":"first","affiliation":[{"name":"Department of Diabetes Complications Research, Steno Diabetes Center Copenhagen Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Diabetes Complications Research, Steno Diabetes Center Copenhagen Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Rosenlund","sequence":"additional","affiliation":[{"name":"Department of Diabetes Complications Research, Steno Diabetes Center Copenhagen Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Eugen\u2010Olsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Clinical Research Centre Copenhagen University Hospital Hvidovre Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Pielak","sequence":"additional","affiliation":[{"name":"Nutopi Sp. z o.o. Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Herlev Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine W.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Diabetes Complications Research, Steno Diabetes Center Copenhagen Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rossing","sequence":"additional","affiliation":[{"name":"Department of Diabetes Complications Research, Steno Diabetes Center Copenhagen Gentofte Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen Copenhagen Denmark"},{"name":"Faculty of Health, Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005121288"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2016.09.016"},{"key":"e_1_2_6_5_1","article-title":"The effect of liraglutide on renal function: a randomized clinical trial","author":"Scholten BJ","journal-title":"Diabetes Obes Metab"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12050"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2015.11.005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12269"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-1852"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0428"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2165"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152512803530388"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-13-49"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-015-0225-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3128"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12594"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2015.04.004"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12884","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T04:52:13Z","timestamp":1761886333000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,2]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/dom.12884"],"URL":"https:\/\/doi.org\/10.1111\/dom.12884","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,2]]}}}