{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:38:53Z","timestamp":1783604333701,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi-Aventis","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,6]]},"abstract":"\n Aims<\/jats:title>\n \n To examine treatment patterns following basal insulin (\n BI<\/jats:styled-content>\n ) introduction in type 2 diabetes mellitus (\n T2DM<\/jats:styled-content>\n ) patients under real\u2010world conditions across\n C<\/jats:styled-content>\n hina.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n Overall, 18\u2009995 patients inadequately controlled (\n HbA1c<\/jats:styled-content>\n \u2009\u2265\u200953\u2009mmol\/mol [7%]) with oral antihyperglycaemic drugs (\n OADs<\/jats:styled-content>\n ) and willing to receive\n BI<\/jats:styled-content>\n treatment were registered at 209 hospitals and followed at baseline (visit 1), 3\u2009months (visit 2) and 6\u2009months (visit 3). Type of\n BI<\/jats:styled-content>\n was initiated at physicians\u2019 discretion.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Retention with\n BI<\/jats:styled-content>\n therapy at 6\u2009months was 75.6%. Use of long\u2010acting\n BI<\/jats:styled-content>\n predominated, with insulin glargine accounting for 71%, detemir 13% and Neutral Protamine Hagedorn (\n NPH<\/jats:styled-content>\n ) insulin 16%. Over 70% of long\u2010acting users maintained the same initial\n BI<\/jats:styled-content>\n at visit 3, while 40% of\n NPH<\/jats:styled-content>\n users switched treatment and 24.4% of participants initiated\n BI<\/jats:styled-content>\n with prandial insulin. The initial mean (\u00b1\n SD<\/jats:styled-content>\n ) dose of\n BI<\/jats:styled-content>\n and total insulin was 0.18\u2009\u00b1\u20090.07 and 0.25\u2009\u00b1\u20090.19\n IU<\/jats:styled-content>\n \/kg, respectively, with a mean increase of daily dose by 0.03 and 0.02\n IU<\/jats:styled-content>\n \/kg after 6\u2009months, respectively. Only 56.6% of insulin users reported dose titration at visit 3. Mean\n HbA1c<\/jats:styled-content>\n was 81\u2009mmol\/mol (9.6%) at baseline and 57\u2009mmol\/mol (7.4%) at 6\u2009months. The frequency of hypoglycaemia was 1.61 and 2.07 episodes\/patient\u2010year at baseline and 6\u2009months, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In real\u2010world clinical settings, add\u2010on\n BI<\/jats:styled-content>\n therapy in\n T2DM<\/jats:styled-content>\n patients is associated with significant improvement in glycaemic control without overtly compromising safety related to hypoglycaemia and weight gain. Evolution of insulin treatment regimens varied among patients, but dose titration was suboptimal. More active\n BI<\/jats:styled-content>\n dose titration might further improve glycaemic outcome in patients receiving\n BI<\/jats:styled-content>\n therapy.\n <\/jats:p>\n <\/jats:sec>\n \n Video Abstract<\/jats:title>\n \n A free Video Abstract to accompany this article is available at\n https:\/\/vimeo.com\/212655959<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12886","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T04:47:23Z","timestamp":1484887643000},"page":"822-830","source":"Crossref","is-referenced-by-count":54,"title":["Observational\n R<\/scp>\n egistry of\n B<\/scp>\n asal\n I<\/scp>\n nsulin\n T<\/scp>\n reatment (\n ORBIT<\/scp>\n ) in patients with type 2 diabetes uncontrolled with oral antihyperglycaemic drugs:\n R<\/scp>\n eal\u2010life use of basal insulin in\n C<\/scp>\n hina"],"prefix":"10.1111","volume":"19","author":[{"given":"Linong","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital Beijing China"},{"name":"The George Institute for Global Health at Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health at Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongshan","family":"Zhu","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health at Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Li","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health at Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachao","family":"Ji","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health at Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Sixth Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangfeng","family":"Wu","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health at Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dajin","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Xiangya Second Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish K.","family":"Garg","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Diabetes University of Colorado Denver Denver 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