{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:12:21Z","timestamp":1772802741834,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1027727"],"award-info":[{"award-number":["1027727"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To determine the effect of\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      criptaid, a compound that can replicate aspects of the exercise adaptive response through disruption of the class\n                      <jats:styled-content style=\"fixed-case\">IIa<\/jats:styled-content>\n                      histone deacetylase (\n                      <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>\n                      ) corepressor complex, on muscle insulin action in obesity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Diet\u2010induced obese mice were administered\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      criptaid (1\u2009mg\/kg) via daily intraperitoneal injection for 4\u2009weeks. Whole\u2010body and skeletal muscle metabolic phenotyping of mice was performed, in addition to echocardiography, to assess cardiac morphology and function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Scriptaid treatment had no effect on body weight or composition, but did increase energy expenditure, supported by increased lipid oxidation, while food intake was also increased.\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      criptaid enhanced the expression of oxidative genes and proteins, increased fatty acid oxidation and reduced triglycerides and diacylglycerides in skeletal muscle. Furthermore,\n                      <jats:italic>ex vivo<\/jats:italic>\n                      insulin\u2010stimulated glucose uptake by skeletal muscle was enhanced. Surprisingly, heart weight was reduced in Scriptaid\u2010treated mice and was associated with enhanced expression of genes involved in oxidative metabolism in the heart. Scriptaid also improved indices of both diastolic and systolic cardiac function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These data show that pharmacological targeting of the class\n                      <jats:styled-content style=\"fixed-case\">IIa HDAC<\/jats:styled-content>\n                      corepressor complex with\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      criptaid could be used to enhance muscle insulin action and cardiac function in obesity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.12896","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T21:12:59Z","timestamp":1486069979000},"page":"936-943","source":"Crossref","is-referenced-by-count":19,"title":["Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice"],"prefix":"10.1111","volume":"19","author":[{"given":"Vidhi","family":"Gaur","sequence":"first","affiliation":[{"name":"Metabolic Research Unit, School of Medicine Deakin University  Geelong Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Connor","sequence":"additional","affiliation":[{"name":"Metabolic Research Unit, School of Medicine Deakin University  Geelong Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kylie","family":"Venardos","sequence":"additional","affiliation":[{"name":"Metabolic Research Unit, School of Medicine Deakin University  Geelong Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren C.","family":"Henstridge","sequence":"additional","affiliation":[{"name":"Metabolism and Inflammation Program Baker IDI Heart and Diabetes Institute  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheree D.","family":"Martin","sequence":"additional","affiliation":[{"name":"Metabolic Research Unit, School of Medicine Deakin University  Geelong Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney","family":"Swinton","sequence":"additional","affiliation":[{"name":"Metabolic Research Unit, School of Medicine Deakin University  Geelong Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shona","family":"Morrison","sequence":"additional","affiliation":[{"name":"Metabolic Research Unit, School of Medicine Deakin University  Geelong Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1412-6715","authenticated-orcid":false,"given":"Kathryn","family":"Aston\u2010Mourney","sequence":"additional","affiliation":[{"name":"Metabolic Research Unit, School of Medicine Deakin University  Geelong Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan M.","family":"Gehrig","sequence":"additional","affiliation":[{"name":"Department of Physiology The University of Melbourne  Parkville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roelof","family":"van Ewijk","sequence":"additional","affiliation":[{"name":"Department of Physiology The University of Melbourne  Parkville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon S.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Physiology The University of Melbourne  Parkville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Febbraio","sequence":"additional","affiliation":[{"name":"Metabolism and Inflammation Program Baker IDI Heart and Diabetes Institute  Melbourne Australia"},{"name":"Division of Diabetes and Metabolism Garvan Institute of Medical Research  Darlinghurst Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory R.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine McMaster University  Hamilton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Hargreaves","sequence":"additional","affiliation":[{"name":"Department of Physiology The University of Melbourne  Parkville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken R.","family":"Walder","sequence":"additional","affiliation":[{"name":"Metabolic Research Unit, School of Medicine Deakin University  Geelong Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6953-106X","authenticated-orcid":false,"given":"Sean L.","family":"McGee","sequence":"additional","affiliation":[{"name":"Metabolic Research Unit, School of Medicine Deakin University  Geelong Australia"},{"name":"Metabolism and Inflammation Program Baker IDI Heart and Diabetes Institute  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-S302"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031314"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117600"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508313330903"},{"key":"e_1_2_6_6_1","first-page":"127","article-title":"Characteristics of GLP\u20101 and exendins action upon glucose transport and metabolism in type 2 diabetic rat skeletal muscle","volume":"22","author":"Arnes L","year":"2008","journal-title":"Int J Mol Med"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199601000-00018"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.051"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1420-x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.08.005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00224-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706487104"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00429-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.181065"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.5.1208"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(88)90110-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120934"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.115.210104"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0843"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-249359"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3273-1"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1865-y"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.10.013"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2419-7"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0410-400"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.04.005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-013-9377-8"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70031-2"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.19.8467-8476.2004"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.150417"},{"key":"e_1_2_6_31_1","volume-title":"Diabetes in America","author":"Geiss LS","year":"1995"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-8-16"},{"key":"e_1_2_6_33_1","first-page":"S2","article-title":"Assessing cardiovascular risk factors and selecting agents to successfully treat patients with type 2 diabetes mellitus","volume":"111","author":"Baldwin MD","year":"2011","journal-title":"J Am Osteopath Assoc"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00861-9"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27438"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303113200"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.625467"},{"key":"e_1_2_6_38_1","first-page":"1351","article-title":"Mitochondrial dysfunction in diabetic cardiomyopathy","volume":"2011","author":"Duncan JG","year":"1813","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80155-0"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.12.3466"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00165.2014"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12896","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:45:49Z","timestamp":1761860749000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,3]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/dom.12896"],"URL":"https:\/\/doi.org\/10.1111\/dom.12896","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,3]]}}}