{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T09:05:32Z","timestamp":1784106332790,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n                    In patients with type 2 diabetes, both supervised exercise and treatment with the glucagon\u2010like peptide\u20101 (\n                    <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\n                    \u20101) receptor agonist (\n                    <jats:styled-content style=\"fixed-case\">GLP\u20101RA<\/jats:styled-content>\n                    ) liraglutide may improve cardiac function. We evaluated cardiac function before and after 16\u2009weeks of treatment with the\n                    <jats:styled-content style=\"fixed-case\">GLP\u20101RA<\/jats:styled-content>\n                    liraglutide or placebo, combined with supervised exercise, in 33 dysregulated patients with type 2 diabetes on diet and\/or metformin. Early diastolic myocardial tissue velocity was improved by exercise in the placebo group (mean\u2009\u00b1\u2009standard deviation [s.d.] \u22127.1\u2009\u00b1\u20091.6 to \u22127.7\u2009\u00b1\u20091.8\u2009cm\/s,\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                    <\/jats:italic>\n                    \u2009\n                    <jats:italic>=<\/jats:italic>\n                    \u2009.01), but not in the liraglutide group (\u22127.1\u2009\u00b1\u20091.4 to \u22127.0\u2009\u00b1\u20091.4\u2009cm\/s,\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                    <\/jats:italic>\n                    \u2009=\u2009.60; between groups,\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                    <\/jats:italic>\n                    \u2009\n                    <jats:italic>=<\/jats:italic>\n                    \u2009.02). Similarly, the mean\u2009\u00b1\u2009s.d. ratio of early and atrial mitral annular tissue velocities improved in the placebo group (1.0\u2009\u00b1\u20090.4 to 1.2\u2009\u00b1\u20090.4,\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                    <\/jats:italic>\n                    \u2009=\u2009.003), but not in the liraglutide group (1.0\u2009\u00b1\u20090.3 to 1.0\u2009\u00b1\u20090.3,\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                    <\/jats:italic>\n                    \u2009=\u2009.87; between groups,\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                    <\/jats:italic>\n                    \u2009=\u2009.03). We found no significant differences in heart rate, left ventricular (\n                    <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\n                    ) structure or function within or between the groups. In conclusion, the addition of liraglutide to exercise in sedentary patients with dysregulated type 2 diabetes may blunt the suggested beneficial effect of exercise on\n                    <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\n                    diastolic function.\n                  <\/jats:p>","DOI":"10.1111\/dom.12900","type":"journal-article","created":{"date-parts":[[2017,2,11]],"date-time":"2017-02-11T08:02:43Z","timestamp":1486800163000},"page":"1040-1044","source":"Crossref","is-referenced-by-count":34,"title":["Effect of exercise combined with glucagon\u2010like peptide\u20101 receptor agonist treatment on cardiac function:\n                    <scp>A<\/scp>\n                    randomized double\u2010blind placebo\u2010controlled clinical trial"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1217-8944","authenticated-orcid":false,"given":"Peter G.","family":"J\u00f8rgensen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Center for Diabetes Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus T.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille","family":"Mensberg","sequence":"additional","affiliation":[{"name":"Center for Diabetes Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Department of Nutrition, Exercise and Sports, Section of Molecular Physiology University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Storgaard","sequence":"additional","affiliation":[{"name":"Center for Diabetes Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Nyby","sequence":"additional","affiliation":[{"name":"Center for Diabetes Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Department of Nutrition, Exercise and Sports, Section of Molecular Physiology University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan S.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2495-5034","authenticated-orcid":false,"given":"Filip K.","family":"Knop","sequence":"additional","affiliation":[{"name":"Center for Diabetes Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Faculty of Health and Medical Sciences, Novo Nordisk Foundation Centre for Basic Metabolic Research University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Vilsb\u00f8ll","sequence":"additional","affiliation":[{"name":"Center for Diabetes Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.165571"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2016.04.046"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.211"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12797"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02869-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.110.959312"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31829ab43c"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e318145b642"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-5-32"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.05.007"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2014.10.013"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506115"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.657"}],"container-title":["Diabetes, 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