{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:44:05Z","timestamp":1761860645838,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sanofi-Aventis (Shanghai, China)"},{"name":"Australian Government's National Collaborative Research Infrastructure Strategy (NCRIS)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,8]]},"abstract":"\n Aims<\/jats:title>\n \n To compare glucose control and safety of different basal insulin therapies (\n BI<\/jats:styled-content>\n , including\n I<\/jats:styled-content>\n nsulin\n NPH<\/jats:styled-content>\n , glargine and detemir) in real\u2010world clinical settings based on a large\u2010scale registry study.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this multi\u2010center 6\u2010month prospective observational study, patients with type 2 diabetes (\n HbA1c<\/jats:styled-content>\n \u2009\u2265\u20097%) who were uncontrolled by oral anti\u2010diabetic drugs (\n OADs<\/jats:styled-content>\n ) and were willing to initiate\n BI<\/jats:styled-content>\n therapy were enrolled from 209 hospitals within 8 regions of\n C<\/jats:styled-content>\n hina. Type and dose of\n BI<\/jats:styled-content>\n were at the physician's discretion and the patients\u2019 willingness. Interviews were conducted at 0\u2009months (visit 1), 3\u2009months (visit 2) and 6\u2009months (visit 3). Outcomes included change in\n HbA1c<\/jats:styled-content>\n , hypoglycemia rate and body weight from baseline at 6\u2009months.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 16\u2009341 and 9002 subjects were involved in\n I<\/jats:styled-content>\n ntention\u2010\n T<\/jats:styled-content>\n o\u2010\n T<\/jats:styled-content>\n reat (\n ITT<\/jats:styled-content>\n ) and per\u2010protocol (\n PP<\/jats:styled-content>\n ) analysis, respectively. After\n PS<\/jats:styled-content>\n regression adjustment,\n ITT<\/jats:styled-content>\n analysis showed that reduction in\n HbA1c<\/jats:styled-content>\n in glargine (2.2%\u2009\u00b1\u20092.1%) and detemir groups (2.2%\u2009\u00b1\u20092.1%) was higher than that in the\n NPH<\/jats:styled-content>\n group (2.0%\u2009\u00b1\u20092.2%) (\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009<\u2009.01). The detemir group had the lowest weight gain (\u22120.1\u2009\u00b1\u20092.9\u2009kg) compared with the glargine (+0.1\u2009\u00b1\u20093.0\u2009kg) and\n NPH<\/jats:styled-content>\n (+0.3\u2009\u00b1\u20093.1\u2009kg) groups (\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009<\u2009.05). The glargine group had the lowest rate of minor hypoglycaemia, while there was no difference in severe hypoglycaemia among the 3 groups. The results observed in\n PP<\/jats:styled-content>\n analyses were consistent with those in\n ITT<\/jats:styled-content>\n analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In a real\u2010world clinical setting in\n C<\/jats:styled-content>\n hina, treatment with long\u2010acting insulin analogues was associated with better glycaemic control, as well as less hypoglycaemia and weight gain than treatment with\n NPH<\/jats:styled-content>\n insulin in type 2 diabetes patients. However, the clinical relevance of these observations must be interpreted with caution.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12920","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T07:46:51Z","timestamp":1487836011000},"page":"1116-1126","source":"Crossref","is-referenced-by-count":11,"title":["Comparative effectiveness and safety of different basal insulins in a real\u2010world setting"],"prefix":"10.1111","volume":"19","author":[{"given":"Linong","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital Beijing P.R. China"},{"name":"Diabetes Research Program The George Institute for Global Health at Peking University Health Science Center Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Diabetes Research Program The George Institute for Global Health at Peking University Health Science Center Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongshan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Diabetes Research Program The George Institute for Global Health at Peking University Health Science Center Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The General Hospital of the People's Liberation Army Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Peking University First Hospital Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangfeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Diabetes Research Program The George Institute for Global Health at Peking University Health Science Center Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Li","sequence":"additional","affiliation":[{"name":"Biostatistics and Economic Evaluation Program The George Institute for Global Health at Peking University Health Science Center Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiachao","family":"Ji","sequence":"additional","affiliation":[{"name":"Biostatistics and Economic Evaluation Program The George Institute for Global Health at Peking University Health Science Center Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology China\u2010Japan Friendship Hospital Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dajin","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Military Medical University Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiguang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Xiangya Second Hospital Changsha P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Peking University First Hospital Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish K.","family":"Garg","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Diabetes University of Colorado Denver Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changyu","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The General Hospital of the People's Liberation Army Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou P.R. 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