{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:16:41Z","timestamp":1792444601890,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:00:00Z","timestamp":1497916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Glucagon\u2010like peptide 1 receptor agonists (\n                      <jats:styled-content style=\"fixed-case\">GLP1\u2010RA<\/jats:styled-content>\n                      ) have been associated with an increased risk of pancreatitis and pancreatic cancer. Prior meta\u2010analyses of randomized controlled trials failed to show any significant increase of risk; however, those meta\u2010analyses did not include the recently published cardiovascular outcome trials (\n                      <jats:styled-content style=\"fixed-case\">CVOT<\/jats:styled-content>\n                      ) with\n                      <jats:styled-content style=\"fixed-case\">GLP1\u2010RA<\/jats:styled-content>\n                      , which provide a substantial additional body of data. The aim of the present meta\u2010analysis is to assess the effect of\n                      <jats:styled-content style=\"fixed-case\">GLP1\u2010RA<\/jats:styled-content>\n                      on pancreatitis, pancreatic cancers and cholelithiasis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      A\n                      <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\n                      edline search for\n                      <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\n                      \u20101 receptor agonists (exenatide, liraglutide, lixisenatide, albiglutide, dulaglutide or semaglutide) was performed, collecting all randomized clinical trials with a duration &gt;11\u2009weeks, enrolling patients with type 2 diabetes and comparing a\n                      <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\n                      \u20101 receptor agonist with placebo or any other non\u2010\n                      <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\n                      \u20101 receptor agonist drug.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 113 trials fulfilling inclusion criteria, 13 did not report information on pancreatitis, whereas 72 reported no events in all treatment groups. The incidence of pancreatitis and pancreatic cancer with\n                      <jats:styled-content style=\"fixed-case\">GLP1\u2010RA<\/jats:styled-content>\n                      was not significantly different from that observed in comparator arms (\n                      <jats:styled-content style=\"fixed-case\">MH\u2010OR<\/jats:styled-content>\n                      [95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ] 0.93 [0.65\u20101.34],\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      <\/jats:italic>\n                      \u2009=\u2009.71, and 0.94 [0.52\u20101.70],\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      <\/jats:italic>\n                      \u2009=\u2009.84, respectively), whereas, a significantly increased risk of cholelithiasis (\n                      <jats:styled-content style=\"fixed-case\">MH\u2010OR<\/jats:styled-content>\n                      [95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ] 1.30 [1.01\u20101.68],\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      <\/jats:italic>\n                      \u2009=\u2009.041) was detected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Presently available data confirm the safety of\n                      <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\n                      \u20101 receptor agonists for pancreatitis. Conversely, therapy with those drugs is associated with an increased risk of cholelithiasis, which deserves further investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.12926","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T08:05:05Z","timestamp":1488269105000},"page":"1233-1241","source":"Crossref","is-referenced-by-count":223,"title":["Safety issues with glucagon\u2010like peptide\u20101 receptor agonists (pancreatitis, pancreatic cancer and cholelithiasis):\n                    <scp>D<\/scp>\n                    ata from randomized controlled trials"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9349-828X","authenticated-orcid":false,"given":"Matteo","family":"Monami","sequence":"first","affiliation":[{"name":"Department of Diabetology Azienda Ospedaliero Universitaria Careggi and University of Florence  Florence 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