{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:08:31Z","timestamp":1790201311383,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,8]]},"abstract":"\n Aims<\/jats:title>\n \n To evaluate short\u2010 and long\u2010term glycaemic control and hypoglycaemia incidence in insulin\u2010na\u00efve patients \u226530\u2009years of age with type 2 diabetes (\n T2DM<\/jats:styled-content>\n ) initiating basal insulin (\n BI<\/jats:styled-content>\n ) with or without oral anti\u2010hyperglycaemic drugs (\n OADs<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was an observational, retrospective longitudinal analysis of electronic medical records from 5\n E<\/jats:styled-content>\n uropean countries and the\n USA<\/jats:styled-content>\n . A multivariable logistic regression model assessed baseline and short\u2010term (0\u20103\u2009months post\n BI<\/jats:styled-content>\n initiation) factors associated with long\u2010term (3\u201024\u2009months) glycaemic control and hypoglycaemia.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Overall, 40\u2009627 patients were included; 20.9% and 27.8% achieved the general\n HbA1c<\/jats:styled-content>\n target of \u22647% at 3 and 24\u2009months post\n BI<\/jats:styled-content>\n initiation, respectively. Failure to achieve\n HbA1c<\/jats:styled-content>\n \u22647% at 3\u2009months was associated with increased risk of failing to achieve target at 24\u2009months (odds ratio [\n OR<\/jats:styled-content>\n ], 3.70 [95%\n CI<\/jats:styled-content>\n , 3.41\u20104.00]). Over 24\u2009months, 8.9% of patients experienced a recorded hypoglycaemic event. Hypoglycaemia during the initial 3\u2010month period was associated with longer\u2010term risk of these events over the ensuing 3 to 24\u2009months (\n OR<\/jats:styled-content>\n , 5.71 [95%\n CI<\/jats:styled-content>\n , 4.67\u20106.99]).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Initiating\n BI<\/jats:styled-content>\n with or without\n OADs<\/jats:styled-content>\n is associated with short\u2010 and long\u2010term suboptimal glycaemic control; the majority of patients fail to achieve\n HbA1c<\/jats:styled-content>\n target \u22647% in the first 3\u2009months, or after 2\u2009years of\n BI<\/jats:styled-content>\n treatment. Treatment response and hypoglycaemia incidence by 3\u2009months post\n BI<\/jats:styled-content>\n initiation are associated with longer\u2010term glycaemic control and hypoglycaemic risk, respectively. These results support the need for early anti\u2010hyperglycaemic interventions that more effectively control blood glucose levels without increasing the risk of hypoglycaemia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.12927","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:18:44Z","timestamp":1488413924000},"page":"1155-1164","source":"Crossref","is-referenced-by-count":110,"title":["Glycaemic control and hypoglycaemia burden in patients with type 2 diabetes initiating basal insulin in\n E<\/scp>\n urope and the\n USA<\/scp>"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2868-0250","authenticated-orcid":false,"given":"D\u00eddac","family":"Mauricio","sequence":"first","affiliation":[{"name":"Department of Endocrinology & Nutrition Hospital Universitari Germans Trias i Pujol, CIBERDEM Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Meneghini","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, University of Texas Southwestern Medical Center Dallas Texas"},{"name":"Parkland Health and Hospital System Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Seufert","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Medicine II, Faculty of Medicine Medical Center \u2013 University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Liao","sequence":"additional","affiliation":[{"name":"Sanofi Bridgewater New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Sanofi Bridgewater New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyue","family":"Tong","sequence":"additional","affiliation":[{"name":"Sanofi Bridgewater New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Cali","sequence":"additional","affiliation":[{"name":"Sanofi Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stella","sequence":"additional","affiliation":[{"name":"Sanofi Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Carita","sequence":"additional","affiliation":[{"name":"Sanofi Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamlesh","family":"Khunti","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre, University of Leicester Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0413"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806470"},{"key":"e_1_2_6_4_1","unstructured":"National Institute for Health and Clinical Excellence.NICE guideline: type 2 diabetes in adults: management.2015.http:\/\/www.nice.org.uk\/guidance\/ng28. Accessed February 14 2017."},{"key":"e_1_2_6_5_1","unstructured":"Working Group of the CPG on type 2 Diabetes 2.Clinical practice guideline for type 2 diabetes [Gu\u00eda de Pr\u00e1ctica Cl\u00ednica sobre Diabetes tipo 2].2010.http:\/\/www.guiasalud.es\/egpc\/traduccion\/ingles\/diabetes\/completa\/index.html. Accessed December 11 2015."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/PGPM.S50288"},{"key":"e_1_2_6_7_1","unstructured":"Haut autorit\u00e9 de la Sant\u00e9.Strat\u00e9gie m\u00e9dicamenteuse du contr\u00f4le glyc\u00e9mique du diab\u00e8te de type 2.2013.http:\/\/www.has\u2010sante.fr\/portail\/upload\/docs\/application\/pdf\/2013\u201002\/reco2clics__diabete_type_2.pdf. Accessed February 14 2017."},{"key":"e_1_2_6_8_1","unstructured":"Programm f\u00fcr Nationale VersorgungsLeitlinien.Therapie des Typ\u20102\u2010Diabetes.2014.http:\/\/www.leitlinien.de\/mdb\/downloads\/nvl\/diabetes\u2010mellitus\/dm\u2010therapie\u20101aufl\u2010vers4\u2010lang.pdf. Accessed February 14 2017."},{"issue":"1","key":"e_1_2_6_9_1","first-page":"S1","article-title":"Standards of medical care in diabetes \u2013 2016","volume":"39","author":"ADA","year":"2016","journal-title":"Diabetes Care"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03605.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.10.2543"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S58781"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2013.08.270"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0331"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.722989"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-015-0260-x"},{"key":"e_1_2_6_17_1","unstructured":"UK Terminology Centre.Read codes.2016.http:\/\/systems.digital.nhs.uk\/data\/uktc\/readcodes. Accessed November 10 2016."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1245"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01602.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12626"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.401"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802987"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2170"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70006-8"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2016.1157462"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13388"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3318-5"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-007-0139-y"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.7.1535"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.3.600"},{"key":"e_1_2_6_32_1","first-page":"e418","article-title":"Clinical inertia in patients with T2DM requiring insulin in family practice","volume":"56","author":"Harris SB","year":"2010","journal-title":"Can Fam Physician"},{"key":"e_1_2_6_33_1","first-page":"455","article-title":"Management of type 2 diabetes with multiple oral hypoglycaemic agents or insulin in primary care: retrospective cohort study","volume":"57","author":"Calvert MJ","year":"2007","journal-title":"Br J Gen Pract"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2016.09.003"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-014-0079-6"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S76855"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01665.x"},{"issue":"1","key":"e_1_2_6_38_1","first-page":"S1","article-title":"Standards of medical care in diabetes \u2013 2015","volume":"38","author":"American Diabetes Association","year":"2015","journal-title":"Diabetes Care"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7258.405"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12438"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-12-23"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3372-z"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12607"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12116"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.07.006"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2013.10.003"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0001"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht108"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110535"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.12.014"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12689"},{"key":"e_1_2_6_52_1","unstructured":"NHS.Diabetes unmet need with basal insulin evaluation.2015.http:\/\/www.hra.nhs.uk\/news\/research\u2010summaries\/diabetes\u2010unmet\u2010need\u2010with\u2010basal\u2010insulin\u2010evaluation\/. Accessed 1 August 2016."}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12927","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:39:41Z","timestamp":1761860381000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,10]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/dom.12927"],"URL":"https:\/\/doi.org\/10.1111\/dom.12927","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,10]]}}}