{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:54:28Z","timestamp":1769064868421,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1DP3DK094292"],"award-info":[{"award-number":["1DP3DK094292"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R24082841"],"award-info":[{"award-number":["1R24082841"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008664","name":"Juvenile Diabetes Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,10]]},"abstract":"\n Diabetic peripheral neuropathy (\n DPN<\/jats:styled-content>\n ) and diabetic kidney disease (\n DKD<\/jats:styled-content>\n ) are common diabetic complications with limited treatment options. Experimental studies show that targeting inflammation using chemokine receptor (\n CCR<\/jats:styled-content>\n ) antagonists ameliorates\n DKD<\/jats:styled-content>\n , presumably by reducing macrophage accumulation or activation. As inflammation is implicated in\n DPN<\/jats:styled-content>\n development, we assessed whether\n CCR2<\/jats:styled-content>\n and\n CCR5<\/jats:styled-content>\n antagonism could also benefit\n DPN<\/jats:styled-content>\n . Five\u2010week\u2010old\n ob\/ob<\/jats:italic>\n mice were fed a diet containing\n MK<\/jats:styled-content>\n \u20100812, a dual\n CCR2\u2010CCR5<\/jats:styled-content>\n receptor antagonist, for 8\u2009weeks;\n DPN<\/jats:styled-content>\n ,\n DKD<\/jats:styled-content>\n and metabolic phenotyping were then performed to determine the effect of\n CCR<\/jats:styled-content>\n inhibition. Although\n MK<\/jats:styled-content>\n \u20100812 reduced macrophage accumulation in adipose tissue, the treatment had largely no effect on metabolic parameters, nerve function or kidney disease in\n ob\/ob<\/jats:italic>\n mice. These results conflict with published data that demonstrate a benefit of\n CCR<\/jats:styled-content>\n antagonists for\n DKD<\/jats:styled-content>\n and hyperglycaemia. We conclude that\n CCR<\/jats:styled-content>\n signaling blockade is ineffective in\n ob\/ob<\/jats:italic>\n mice and suspect that this is explained by the severe hyperglycaemia found in this model. It remains to be determined whether\n MK<\/jats:styled-content>\n \u20100812 treatment, alone or in combination with improved glycaemic control, is useful in preventing diabetic complications in alternate animal models.\n <\/jats:p>","DOI":"10.1111\/dom.12950","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:29:28Z","timestamp":1490315368000},"page":"1468-1472","source":"Crossref","is-referenced-by-count":17,"title":["Dual\n CCR2<\/scp>\n \/\n CCR5<\/scp>\n antagonist treatment attenuates adipose inflammation, but not microvascular complications in\n ob\/ob<\/i>\n mice"],"prefix":"10.1111","volume":"19","author":[{"given":"Phillipe D.","family":"O'Brien","sequence":"first","affiliation":[{"name":"Department of Neurology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy M.","family":"Hinder","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian D.","family":"Parlee","sequence":"additional","affiliation":[{"name":"Department of Molecular & Integrative Physiology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carey","family":"Backus","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiometabolic Disease Merck Research Laboratories Kenilworth New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey A.","family":"Sakowski","sequence":"additional","affiliation":[{"name":"A. Alfred Taubman Medical Research Institute University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Frank C.","family":"Brosius","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9162-2694","authenticated-orcid":false,"given":"Eva L.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"},{"issue":"5","key":"e_1_2_6_3_1","first-page":"004","article-title":"Inflammatory mediators in diabetic neuropathy","author":"Wilson NM","year":"2011","journal-title":"J Diabetes Metab"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.51"},{"key":"e_1_2_6_5_1","first-page":"CD007543","article-title":"Enhanced glucose control for preventing and treating diabetic neuropathy","author":"Callaghan BC","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-015-0612-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2006.00576.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1403"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2385"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2013.06.008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.263"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00261-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2741\/2734"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.10.015"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009121290"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000113551.14276.0B"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12950","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T04:37:03Z","timestamp":1761885423000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,2]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/dom.12950"],"URL":"https:\/\/doi.org\/10.1111\/dom.12950","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,2]]}}}