{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:11Z","timestamp":1787014091843,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T00:00:00Z","timestamp":1499644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,12]]},"abstract":"\n The beneficial effects of mineralocorticoid receptor blockade by spironolactone have been shown in animal models of non\u2010alcoholic fatty liver disease (\n NAFLD<\/jats:styled-content>\n ). The aim of the present 52\u2010week randomized controlled trial was to compare the effects of low\u2010dose spironolactone and vitamin E combination with those of vitamin E monotherapy on insulin resistance, non\u2010invasive indices of hepatic steatosis and fibrosis, liver function tests, circulating adipokines and hormones in patients with histologically confirmed\n NAFLD<\/jats:styled-content>\n . Homeostasis model of assessment of insulin resistance (\n HOMA\u2010IR<\/jats:styled-content>\n ) and non\u2010invasive indices of steatosis and fibrosis were calculated. Analysis was intention\u2010to\u2010treat.\n NAFLD<\/jats:styled-content>\n liver fat score, an index of steatosis, decreased significantly in the combination treatment group (\n P<\/jats:italic>\n = .028), but not in the vitamin E group, and the difference for group*time interaction was significant (\n P<\/jats:italic>\n = .047). Alanine aminotransferase\u2010to\u2010platelet ratio index, an index of fibrosis, did not change. Insulin levels and\n HOMA\u2010IR<\/jats:styled-content>\n decreased significantly only within the combination group (\n P<\/jats:italic>\n = .011 and\n P<\/jats:italic>\n = .011, respectively). In conclusion, the combined low\u2010dose spironolactone plus vitamin E regimen significantly decreased\n NAFLD<\/jats:styled-content>\n liver fat score. Larger\u2010scale trials are needed to clarify the effect of low\u2010dose spironolactone on hepatic histology.\n <\/jats:p>","DOI":"10.1111\/dom.12989","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T03:46:42Z","timestamp":1493351202000},"page":"1805-1809","source":"Crossref","is-referenced-by-count":76,"title":["Effects of combined low\u2010dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non\u2010invasive indices of steatosis and fibrosis, and adipokine levels in non\u2010alcoholic fatty liver disease:\n a<\/scp>\n randomized controlled trial"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9232-4042","authenticated-orcid":false,"given":"Stergios A.","family":"Polyzos","sequence":"first","affiliation":[{"name":"Second Medical Clinic, School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannis","family":"Kountouras","sequence":"additional","affiliation":[{"name":"Second Medical Clinic, School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos S.","family":"Mantzoros","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaia","family":"Polymerou","sequence":"additional","affiliation":[{"name":"Department of Biopathology, Biomedicine Laboratories Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Katsinelos","sequence":"additional","affiliation":[{"name":"Second Medical Clinic, School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.5370"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2016.1225727"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01403.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12918"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12809"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31824587e0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3902-y"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163069"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2009.01176.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0869"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2006.03.007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00419.2013"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12794"},{"issue":"3","key":"e_1_2_6_15_1","first-page":"407","article-title":"Selective aldosterone blocker ameliorates the progression of non\u2010alcoholic steatohepatitis in rats","volume":"26","author":"Noguchi R","year":"2010","journal-title":"Int J Mol Med"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-015-0541-6"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01377.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c869"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1470320311402110"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0640-8"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.12989","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.12989","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.12989","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.12989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T05:36:00Z","timestamp":1761888960000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.12989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,10]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/dom.12989"],"URL":"https:\/\/doi.org\/10.1111\/dom.12989","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,10]]}}}