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Although glucocentric therapies may improve glycaemic control (as determined by glycated haemoglobin levels), evidence suggests that this approach alone has limited beneficial effects on\n                    <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>\n                    outcomes relative to improvements in lipid and blood pressure control. This may be explained in part by the fact that current antidiabetic treatment regimens primarily address overall glycaemia and\/or fasting plasma glucose, but not the postprandial plasma glucose (\n                    <jats:styled-content style=\"fixed-case\">PPG<\/jats:styled-content>\n                    ) excursions that have a fundamental causative role in increasing\n                    <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>\n                    risk. This literature review evaluates the relationship between\n                    <jats:styled-content style=\"fixed-case\">PPG<\/jats:styled-content>\n                    and the risk of\n                    <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>\n                    disease, discusses the treatment of\n                    <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>\n                    with glucagon\u2010like peptide\u20101 receptor agonists (\n                    <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\n                    \u20101\n                    <jats:styled-content style=\"fixed-case\">RAs<\/jats:styled-content>\n                    ) and examines the associated\n                    <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>\n                    outcomes. The literature analysis suggests that exaggerated\n                    <jats:styled-content style=\"fixed-case\">PPG<\/jats:styled-content>\n                    excursions are a risk factor for\n                    <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>\n                    disease because of their adverse pathophysiologic effects on the vasculature, resulting in increased all\u2010cause and\n                    <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>\n                    \u2010related mortality. Although\n                    <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\n                    \u20101\n                    <jats:styled-content style=\"fixed-case\">RAs<\/jats:styled-content>\n                    are well established in the current\n                    <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>\n                    treatment paradigm, a subgroup of these compounds has a particularly pronounced, persistent and short\u2010lived effect on gastric emptying and, hence, lower\n                    <jats:styled-content style=\"fixed-case\">PPG<\/jats:styled-content>\n                    substantially. However, current long\u2010term data on\n                    <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>\n                    outcomes with\n                    <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\n                    \u20101\n                    <jats:styled-content style=\"fixed-case\">RAs<\/jats:styled-content>\n                    are contradictory, with both beneficial and adverse effects having been reported. This review explores the opportunity to direct treatment towards controlling\n                    <jats:styled-content style=\"fixed-case\">PPG<\/jats:styled-content>\n                    excursions, thereby improving not only overall glycaemic control but also\n                    <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>\n                    outcomes.\n                  <\/jats:p>","DOI":"10.1111\/dom.12998","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:33:40Z","timestamp":1493944420000},"page":"1645-1654","source":"Crossref","is-referenced-by-count":25,"title":["A review of glucagon\u2010like peptide\u20101 receptor agonists and their effects on lowering postprandial plasma glucose and cardiovascular outcomes in the treatment of type 2 diabetes mellitus"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1002-1238","authenticated-orcid":false,"given":"David R.","family":"Owens","sequence":"first","affiliation":[{"name":"Diabetes Research Group, Institute of Life Sciences College of Medicine Swansea University  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Monnier","sequence":"additional","affiliation":[{"name":"Laboratory of Human Nutrition and Atherosclerosis, Institute of Clinical Research University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7323-1203","authenticated-orcid":false,"given":"Markolf","family":"Hanefeld","sequence":"additional","affiliation":[{"name":"Study Centre \u201cProfessor Hanefeld\u201d GWT\u2010Technical University Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,11]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1065","article-title":"Self\u2010reported heart disease and stroke among 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