{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:49:34Z","timestamp":1784562574755,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2017,12]]},"abstract":"\n Aims<\/jats:title>\n \n Studies comparing reperfusion efficacy and myocardial damage between diabetic and non\u2010diabetic patients with\n ST<\/jats:styled-content>\n \u2010elevation myocardial infarction (\n STEMI<\/jats:styled-content>\n ) are scarce and have reported conflicting results. The aim was to investigate the impact of preadmission diabetic status on myocardial salvage and damage as determined by cardiac magnetic resonance (\n CMR<\/jats:styled-content>\n ), and to evaluate its prognostic relevance.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n We enrolled 792 patients with\n STEMI<\/jats:styled-content>\n at 8 sites.\n CMR<\/jats:styled-content>\n core laboratory analysis was performed to determine infarct characteristics. Major adverse cardiac events (\n MACE<\/jats:styled-content>\n ), defined as a composite of all\u2010cause death, non\u2010fatal re\u2010infarction and new congestive heart failure, were recorded at 12 months. Patients were categorized according to preexisting diabetes mellitus (\n DM<\/jats:styled-content>\n ), and according to insulin\u2010treated\n DM<\/jats:styled-content>\n (\n ITDM<\/jats:styled-content>\n ) and non\u2010insulin\u2010treated\n DM<\/jats:styled-content>\n (\n NITDM<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One\u2010hundred and sixty (20%) patients had\n DM<\/jats:styled-content>\n and 74 (9%) were insulin\u2010treated. There was no difference in the myocardial salvage index, infarct size, microvascular obstruction and left ventricular ejection fraction between all patient groups (all\n P<\/jats:italic>\n > .05). Patients with\n DM<\/jats:styled-content>\n were at higher risk of\n MACE<\/jats:styled-content>\n (11% vs 6%,\n P<\/jats:italic>\n = .03) than non\u2010\n DM<\/jats:styled-content>\n patients. After stratification according to preadmission anti\u2010diabetic therapy,\n MACE<\/jats:styled-content>\n rate was comparable between\n NITDM<\/jats:styled-content>\n and non\u2010\n DM<\/jats:styled-content>\n (\n P<\/jats:italic>\n > .05), whereas the group of\n ITDM<\/jats:styled-content>\n patients had significantly worse outcome (\n P<\/jats:italic>\n < .001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Diabetic patients with\n STEMI<\/jats:styled-content>\n , especially those having\n ITDM<\/jats:styled-content>\n , had an increased risk of\n MACE<\/jats:styled-content>\n . The adverse clinical outcome was, however, not explained by an impact of\n DM<\/jats:styled-content>\n on reperfusion success or myocardial damage.\n <\/jats:p>\n \n Clinical trial registry number:\n NCT00712101<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.13002","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T05:04:56Z","timestamp":1493960696000},"page":"1706-1713","source":"Crossref","is-referenced-by-count":38,"title":["Relationship between diabetes and ischaemic injury among patients with revascularized\n ST<\/scp>\n \u2010elevation myocardial infarction"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7700-1357","authenticated-orcid":false,"given":"Sebastian J.","family":"Reinstadler","sequence":"first","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck, Medical Clinic II University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck L\u00fcbeck Germany"},{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Stiermaier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck, Medical Clinic II University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Eitel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck, Medical Clinic II University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Metzler","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"de Waha","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck, Medical Clinic II University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Fuernau","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck, Medical Clinic II University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Desch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck, Medical Clinic II University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck, Medical Clinic II University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"German 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