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To design the\n                    <jats:styled-content style=\"fixed-case\">RISE<\/jats:styled-content>\n                    study, we undertook an evaluation of methods for measurement of \u03b2\u2010cell function and changes in \u03b2\u2010cell function in response to interventions. In the present paper, we review approaches for measurement of \u03b2\u2010cell function, focusing on methodologic and feasibility considerations. Methodologic considerations included: (1) the utility of each technique for evaluating key aspects of \u03b2\u2010cell function (first\u2010 and second\u2010phase insulin secretion, maximum insulin secretion, glucose sensitivity, incretin effects) and (2) tactics for incorporating a measurement of insulin sensitivity in order to adjust insulin secretion measures for insulin sensitivity appropriately. Of particular concern were the capacity to measure \u03b2\u2010cell function accurately in those with poor function, as is seen in established\n                    <jats:styled-content style=\"fixed-case\">T2D<\/jats:styled-content>\n                    , and the capacity of each method for demonstrating treatment\u2010induced changes in \u03b2\u2010cell function. Feasibility considerations included: staff burden, including time and required methodological expertise; participant burden, including time and number of study visits; and ease of standardizing methods across a multicentre consortium. After this evaluation, we selected a 2\u2010day measurement procedure, combining a 3\u2010hour 75\u2010g oral glucose tolerance test and a 2\u2010stage hyperglycaemic clamp procedure, augmented with arginine.\n                  <\/jats:p>","DOI":"10.1111\/dom.13005","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T11:25:58Z","timestamp":1494501958000},"page":"14-24","source":"Crossref","is-referenced-by-count":79,"title":["Review of methods for measuring \u03b2\u2010cell function:\n                    <scp>D<\/scp>\n                    esign considerations from the\n                    <scp>R<\/scp>\n                    estoring\n                    <scp>I<\/scp>\n                    nsulin\n                    <scp>S<\/scp>\n                    ecretion (\n                    <scp>RISE<\/scp>\n                    )\n                    <scp>C<\/scp>\n                    onsortium"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8792-4278","authenticated-orcid":false,"given":"Tamara S.","family":"Hannon","sequence":"first","affiliation":[{"name":"Departments of Pediatrics (T. 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