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The initiation of\n                    <jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>\n                    improves glycaemic control and reduces the risk of microvascular complications. There is, however, an associated weight gain following\n                    <jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>\n                    , which may adversely affect diabetic and cardiovascular morbidity and mortality. A 3 to 9 kg insulin\u2010associated weight gain (\n                    <jats:styled-content style=\"fixed-case\">IAWG<\/jats:styled-content>\n                    ) is reported to occur in the first year of initiating\n                    <jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>\n                    , predominantly caused by adipose tissue. The potential causes for this weight gain include an increase in energy intake linked to a fear of hypoglycaemia, a reduction in glycosuria, catch\u2010up weight, and central effects on weight and appetite regulation. Patients with type 2 diabetes who are receiving\n                    <jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>\n                    often have multiple co\u2010morbidities, including obesity, that are exacerbated by weight gain, making the management of their diabetes and obesity challenging. There are several treatment strategies for patients with type 2 diabetes, who require\n                    <jats:styled-content style=\"fixed-case\">IT<\/jats:styled-content>\n                    , that attenuate weight gain, help improve glycaemic control, and help promote body weight homeostasis. This review addresses the effects of insulin initiation and intensification on\n                    <jats:styled-content style=\"fixed-case\">IAWG<\/jats:styled-content>\n                    , and explores its potential underlying mechanisms, the predictors for this weight gain, and the available treatment options for managing and limiting weight gain.\n                  <\/jats:p>","DOI":"10.1111\/dom.13009","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T05:28:46Z","timestamp":1494912526000},"page":"1655-1668","source":"Crossref","is-referenced-by-count":101,"title":["Insulin\u2010associated weight gain in obese type 2 diabetes mellitus patients: What can be done?"],"prefix":"10.1111","volume":"19","author":[{"given":"Adrian","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Nutrition and Dietetic Research Group Imperial College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Guess","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Nutrition and Dietetic Research Group Imperial College  London UK"},{"name":"Division of Diabetes and Nutritional Sciences Kings College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Dornhorst","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8314-1500","authenticated-orcid":false,"given":"Shahrad","family":"Taheri","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine Imperial College London  London UK"},{"name":"Department of Medicine and Clinical Research Core Weill Cornell Medicine  New York New York"},{"name":"Department of Medicine and Clinical Research Core Weill Cornell Medicine  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Frost","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Nutrition and Dietetic Research Group Imperial College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,13]]},"reference":[{"key":"e_1_2_19_2_1","unstructured":"World Health Organization.Global report on diabetes;2016:1\u201388. 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