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Recent advances in molecular technologies, in particular single\u2010cell profiling on both the protein and messenger RNA level, have uncovered that \u03b2\u2010cells exist in several antigenically and molecularly definable states. Using antibodies to cell surface markers or multidimensional clustering of \u03b2\u2010cells using more than 20 protein markers by mass cytometry, 4 distinct groups of \u03b2\u2010cells could be differentiated. However, whether these states represent permanent cell lineages or are readily interconvertible from one group to another remains to be determined. Nevertheless, future analysis of the pathogenesis of type 1 and type 2 diabetes will certainly benefit from a growing appreciation of \u03b2\u2010cell heterogeneity. Here, we aim to summarize concisely the recent advances in the field and their possible impact on our understanding of \u03b2\u2010cell physiology and pathophysiology.<\/jats:p>","DOI":"10.1111\/dom.13019","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T15:00:03Z","timestamp":1504796403000},"page":"147-152","source":"Crossref","is-referenced-by-count":26,"title":["\u03b2\u2010Cells are not uniform after all\u2014Novel insights into molecular heterogeneity of insulin\u2010secreting cells"],"prefix":"10.1111","volume":"19","author":[{"given":"Dana","family":"Avrahami","sequence":"first","affiliation":[{"name":"Endocrinology and Metabolism Service, Department of Internal Medicine Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Genetics and Institute for Diabetes, Obesity, and Metabolism 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