{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:43:17Z","timestamp":1790008997675,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    The aim was to determine the effects of dulaglutide, a synthetic once\u2010weekly, injectable human glucagon\u2010like peptide 1 analogue that lowers blood glucose, body weight, appetite and blood pressure, on cardiovascular outcomes. People with type 2 diabetes, aged \u226550\u2009years, with glycated haemoglobin (\n                    <jats:styled-content style=\"fixed-case\">HbA1c<\/jats:styled-content>\n                    ) \u22649.5%, and either a previous cardiovascular event, evidence of cardiovascular disease or \u22652 cardiovascular risk factors were randomly allocated to a weekly subcutaneous injection of either dulaglutide (1.5\u2009mg) or placebo and followed within the ongoing\n                    <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\n                    esearching cardiovascular\n                    <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                    vents with a\n                    <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>\n                    eekly\n                    <jats:styled-content style=\"fixed-case\">IN<\/jats:styled-content>\n                    cretin in\n                    <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                    iabetes (\n                    <jats:styled-content style=\"fixed-case\">REWIND<\/jats:styled-content>\n                    ) trial every 3 to 6\u2009months. The primary cardiovascular outcome is the first occurrence of the composite of cardiovascular death or non\u2010fatal myocardial infarction or non\u2010fatal stroke. Secondary outcomes include each component of the primary composite cardiovascular outcome, a composite clinical microvascular outcome comprising retinal or renal disease, hospitalization for unstable angina, heart failure requiring hospitalization or an urgent heart failure visit, and all\u2010cause mortality. Follow\u2010up will continue until the accrual of 1200 confirmed primary outcomes. Recruitment of 9901 participants (mean age 66\u2009years, 46% women) occurred in 370 sites located in 24 countries over a period of 2\u2009years. The mean duration of diabetes was 10\u2009years, mean baseline HbA1c was 7.3%, and 31% had prior cardiovascular disease. The REWIND trial's international scope, high proportion of women, high proportion of people without prior cardiovascular disease and inclusion of participants whose mean baseline HbA1c was 7.3% suggests that its cardiovascular and safety findings will be directly relevant to the typical middle\u2010aged patient seen in general practice throughout the world.\n                  <\/jats:p>","DOI":"10.1111\/dom.13028","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:52:37Z","timestamp":1496364757000},"page":"42-49","source":"Crossref","is-referenced-by-count":159,"title":["Design and baseline characteristics of participants in the\n                    <scp>R<\/scp>\n                    esearching cardiovascular\n                    <scp>E<\/scp>\n                    vents with a\n                    <scp>W<\/scp>\n                    eekly\n                    <scp>IN<\/scp>\n                    cretin in\n                    <scp>D<\/scp>\n                    iabetes (\n                    <scp>REWIND<\/scp>\n                    ) trial on the cardiovascular effects of dulaglutide"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8072-2836","authenticated-orcid":false,"given":"Hertzel C.","family":"Gerstein","sequence":"first","affiliation":[{"name":"Department of Medicine and Population Health Research Institute McMaster University and Hamilton Health Sciences  Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.","family":"Colhoun","sequence":"additional","affiliation":[{"name":"University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles R.","family":"Dagenais","sequence":"additional","affiliation":[{"name":"Universite Laval  Quebec City Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Diaz","sequence":"additional","affiliation":[{"name":"ECLA Academic Research 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