{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:10:15Z","timestamp":1778339415084,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Merck Sharp & Dohme (MSD) Portugal"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To analyse the prevalence of severe hypoglycaemia in patients with type 2 diabetes (\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      2\n                      <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                      ) treated with antihyperglycaemic agents (\n                      <jats:styled-content style=\"fixed-case\">AHA<\/jats:styled-content>\n                      ) and requiring emergency room (\n                      <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                      ) assistance, and to analyse the prevalence according to type of\n                      <jats:styled-content style=\"fixed-case\">AHA<\/jats:styled-content>\n                      therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The present study, the\n                      <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                      ypoglycaemia\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      n\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      ortugal\n                      <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>\n                      bservational\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      tudy\u2013\n                      <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                      mergency\n                      <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\n                      oom (\n                      <jats:styled-content style=\"fixed-case\">HIPOS<\/jats:styled-content>\n                      \u2013\n                      <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                      ), was a cross\u2010sectional, observational, multicentre, nationwide study, with specific hypoglycaemia source data collection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Within the study period, a total of 425\u2009706 admissions were recorded in the\n                      <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                      s of participating hospitals. The prevalence of severe hypoglycaemic episodes in patients with T2DM was 0.074%. In all, 238 patients were included, more than half of whom were on insulin\u2010based therapy (55.0%) and a third of whom (31.5%) were on oral secretagogue\u2010based therapy. In 61.2% of patients primary care was the main diabetes care setting. The median patient age was 77.5\u2009years and the mean duration of diabetes was 19\u2009years. Missing a meal or low carbohydrate meal content was the most frequent cause of hypoglycaemia (55.9%) and the most frequent triggers for seeking emergency assistance were pre\u2010syncope (19.2%) and transient loss of consciousness (17.4%). A total of 44.1% of patients were hospitalized for a median of 5.1\u2009days. Patients in the secretagogue group were admitted to hospital more often than patients in the insulin group (70.7% vs 29.0%;\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>P<\/jats:italic>\n                      <\/jats:styled-content>\n                      \u2009&lt;\u2009.001). Nine patients died.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These findings confirm that severe hypoglycaemia in patients with\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      2\n                      <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                      requiring\n                      <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                      assistance occurs mainly in those on insulin\u2010 and secretagogue\u2010based therapies and is associated with a significant medical burden. Antidiabetic therapy should be individualized to minimize the risk of severe iatrogenic hypoglycaemia, and any intervention to this end should always involve primary care stakeholders.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13030","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T06:56:42Z","timestamp":1496645802000},"page":"50-59","source":"Crossref","is-referenced-by-count":21,"title":["Severe hypoglycaemia among patients with type 2 diabetes requiring emergency hospital admission:\n                    <scp>T<\/scp>\n                    he\n                    <scp>H<\/scp>\n                    ypoglycaemia\n                    <scp>I<\/scp>\n                    n\n                    <scp>P<\/scp>\n                    ortugal\n                    <scp>O<\/scp>\n                    bservational\n                    <scp>S<\/scp>\n                    tudy\u2013\n                    <scp>E<\/scp>\n                    mergency\n                    <scp>R<\/scp>\n                    oom (\n                    <scp>HIPOS<\/scp>\n                    \u2013\n                    <scp>ER<\/scp>\n                    )"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5973-8662","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Concei\u00e7\u00e3o","sequence":"first","affiliation":[{"name":"Medical Affairs MSD International GmbH (Singapore Branch)  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Dores","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Emergency Department Centro Hospitalar do Porto  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Beatriz \u00c2ngelo Hospital  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro A.","family":"Laires","sequence":"additional","affiliation":[{"name":"Outcomes Research Department MSD Portugal  Pa\u00e7o de Arcos Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard D.","family":"Carr","sequence":"additional","affiliation":[{"name":"MSD Europe Canada, Global Medical Affairs Organization  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Brodovicz","sequence":"additional","affiliation":[{"name":"Global Epidemiology, Merck &amp; Co.  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