{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:12:13Z","timestamp":1791727933751,"version":"4.3.4"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Herlev Gentofte Hospital Research Foundation, the Department of Internal Medicine"},{"name":"Herlev Gentofte Hospital and an unrestricted grant"},{"name":"Novo Nordisk A\/S"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,1]]},"abstract":"\n Women with polycystic ovary syndrome (\n PCOS<\/jats:styled-content>\n ) were treated with the\n GLP<\/jats:styled-content>\n \u20101 receptor agonist liraglutide to investigate the effect on liver fat content, visceral adipose tissue (\n VAT<\/jats:styled-content>\n ) and the prevalence of nonalcoholic fatty liver disease (\n NAFLD<\/jats:styled-content>\n ). In a double\u2010blind, placebo\u2010controlled, randomized clinical trial 72 women with\n PCOS<\/jats:styled-content>\n , with a\n BMI<\/jats:styled-content>\n \u2009>\u200925\u2009kg\/m\n 2<\/jats:sup>\n and\/or insulin resistance, were treated with liraglutide or received placebo 1.8\u2009mg\/d (2:1) for 26\u2009weeks. Liver fat content was assessed by\n 1<\/jats:sup>\n HMR<\/jats:styled-content>\n spectroscopy,\n VAT<\/jats:styled-content>\n by\n MRI<\/jats:styled-content>\n , body composition by\n DXA<\/jats:styled-content>\n , and glucose metabolism by oral glucose tolerance test. Compared with placebo, liraglutide treatment reduced body weight by 5.2\u2009kg (5.6%), liver fat content by 44%,\n VAT<\/jats:styled-content>\n by 18%, and the prevalence of\n NAFLD<\/jats:styled-content>\n by two\u2010thirds (all\n P<\/jats:italic>\n \u2009<\u2009.01). Sex\u2010hormone\u2010binding\u2010globulin (\n SHBG<\/jats:styled-content>\n ) levels increased by 19% (\n P<\/jats:italic>\n \u2009=\u2009.03), and free testosterone decreased by 19% (\n P<\/jats:italic>\n \u2009=\u2009.054).\n H<\/jats:styled-content>\n b\n A<\/jats:styled-content>\n 1c, fasting glucose and leptin were reduced (all:\n P<\/jats:italic>\n \u2009<\u2009.05), whereas measures of insulin resistance, adiponectin and glucagon did not change. In conclusion, 26\u2009weeks of liraglutide treatment in\n PCOS<\/jats:styled-content>\n resulted in significant reductions in liver fat content,\n VAT<\/jats:styled-content>\n and the prevalence of\n NAFLD<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/dom.13053","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T05:06:47Z","timestamp":1499317607000},"page":"215-218","source":"Crossref","is-referenced-by-count":171,"title":["Effect of liraglutide on ectopic fat in polycystic ovary syndrome:\n A<\/scp>\n randomized clinical trial"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2630-1210","authenticated-orcid":false,"given":"Signe","family":"Fr\u00f8ssing","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Center of Endocrinology and Metabolism Herlev Gentofte Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Nylander","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Herlev Gentofte Hospital Copenhagen Denmark"},{"name":"Faculty of Health and Medical Sciences Copenhagen University Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta","family":"Chabanova","sequence":"additional","affiliation":[{"name":"Department of Radiology Herlev Gentofte Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Frystyk","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Health, Medical Research Laboratory Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens J.","family":"Holst","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences Copenhagen University Copenhagen Denmark"},{"name":"Department of Biomedical Sciences, NNF Center for Basic Metabolic Research Copenhagen University Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Kistorp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center of Endocrinology and Metabolism Herlev Gentofte Hospital Copenhagen Denmark"},{"name":"Faculty of Health and Medical Sciences Copenhagen University Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven O.","family":"Skouby","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Herlev Gentofte Hospital Copenhagen Denmark"},{"name":"Faculty of Health and Medical Sciences Copenhagen University Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center of Endocrinology and Metabolism Herlev Gentofte Hospital Copenhagen Denmark"},{"name":"Faculty of Health and Medical Sciences Copenhagen University Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1290"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.23235"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-015-0005-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/07435800.2014.966385"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12369"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0115"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401383"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-16-0113"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00803-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.013"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-015-3976-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2011-1034"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.01.057"}],"container-title":["Diabetes, 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