{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:07:23Z","timestamp":1789448843352,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>\n                    In this\n                    <jats:italic>post hoc<\/jats:italic>\n                    analysis we compared glycaemic control and hypoglycaemia between insulin glargine 300 U\/mL (Gla\u2010300) and glargine 100 U\/mL (Gla\u2010100) administered once daily in people with type 2 diabetes (T2DM) from the EDITION 1 (basal plus mealtime insulin) and EDITION 2 (basal insulin plus oral antihyperglycaemic drugs) trials who were previously receiving twice\u2010daily insulin. At randomization, 16.9% and 20.0% of people in EDITION 1 and 2, respectively, were receiving twice\u2010daily basal insulin. Glycated haemoglobin change from baseline to Month 6 was similar over 6 months with Gla\u2010300 or Gla\u2010100 (least squares mean difference \u22120.01%; 95% confidence interval [CI] \u22120.27 to 0.24] in EDITION 1 and 0.16%; 95% CI \u22120.25 to 0.57, in EDITION 2). Participants previously receiving twice\u2010daily insulin in EDITION 1 had a lower risk of confirmed (\u22643.9 mmol\/L [\u226470 mg\/dL]) or severe hypoglycaemia with Gla\u2010300 vs Gla\u2010100 at night (00:00\u201305:59 hours), but not at any time (24 hours); in EDITION 2 the risk was reduced at night and any time (24 hours). In conclusion, Gla\u2010300 provided similar glycaemic control with less hypoglycaemia compared with Gla\u2010100 in people with T2DM switching from twice\u2010daily to once\u2010daily basal insulin.\n                  <\/jats:p>","DOI":"10.1111\/dom.13071","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T01:16:41Z","timestamp":1500859001000},"page":"448-452","source":"Crossref","is-referenced-by-count":7,"title":["Glycaemic control and hypoglycaemia in people with type 2 diabetes switching from twice\u2010daily basal insulin to once\u2010daily insulin glargine 300 U\/mL or insulin glargine 100 U\/mL (\n                    <scp>EDITION<\/scp>\n                    1 and\n                    <scp>EDITION<\/scp>\n                    2 subgroup analysis)"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-8363","authenticated-orcid":false,"given":"Ronan","family":"Roussel","sequence":"first","affiliation":[{"name":"INSERM, UMRS 1138 Centre de Recherche des Cordeliers  Paris France"},{"name":"D\u00e9partement Hospitalo\u2010Universitaire FIRE, Service de Diab\u00e9tologie, Endocrinologie et Nutrition UFR de M\u00e9decine, and Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Bichat, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"d'Emden","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Royal Brisbane and Women's Hospital  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Clinical Pharmacology Glasgow Royal Infirmary  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Javier","family":"Ampudia\u2010Blasco","sequence":"additional","affiliation":[{"name":"Diabetes Reference Unit Clinic University Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stella","sequence":"additional","affiliation":[{"name":"Sanofi  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Bizet","sequence":"additional","affiliation":[{"name":"Sanofi  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M. G.","family":"Cali","sequence":"additional","affiliation":[{"name":"Sanofi  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol H.","family":"Wysham","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology Center Rockwood Clinic  Spokane Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2005.0117.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03605.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229681300700527"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2008.0023"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2500"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.11.2673"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.10.2543"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12304"},{"issue":"4","key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.2337\/dc14-0006","article-title":"New insulin glargine 300 Units.mL\u20101 provides a more even activity profile and prolonged glycemic control at steady state compared with insulin glargine 100 Units.mL\u20101","volume":"38","author":"Becker RH","year":"2015","journal-title":"Diabetes Care"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12416"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12485"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0990"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0991"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1245"},{"key":"e_1_2_6_16_1","first-page":"S1","article-title":"Standards of medical care in diabetes","volume":"40","author":"American Diabetes Association","year":"2017","journal-title":"Diabetes Care"},{"key":"e_1_2_6_17_1","unstructured":"Sanofi. 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Accessed May 20 2015."}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdom.13071","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.13071","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.13071","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.13071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:01:50Z","timestamp":1761872510000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.13071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,14]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/dom.13071"],"URL":"https:\/\/doi.org\/10.1111\/dom.13071","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,14]]}}}