{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:31:14Z","timestamp":1791901874285,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,24]],"date-time":"2017-09-24T00:00:00Z","timestamp":1506211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Stanford University SPARK programme"},{"name":"KL2 Mentored Career Development Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the efficacy, pharmacokinetic (PK) profile and tolerability of subcutaneous (s.c.). exendin 9\u201039 (Ex\u20109) injection in patients with post\u2010bariatric hypoglycaemia (PBH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nine women who had recurrent symptomatic hypoglycaemia after undergoing Roux\u2010en\u2010Y gastric bypass were enrolled in this 2\u2010part, single\u2010blind, single\u2010ascending\u2010dose study. In Part 1, a single participant underwent equimolar low\u2010dose intravenous (i.v.) vs s.c. Ex\u20109 administration; in Part 2, 8 participants were administered single ascending doses of s.c. Ex\u20109 during an oral glucose tolerance test (OGTT). Glycaemic, hormonal, PK and symptomatic responses were compared with those obtained during the baseline OGTT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although an exposure\u2013response relationship was observed, all doses effectively prevented hyperinsulinaemic hypoglycaemia and improved associated symptoms. On average, the postprandial glucose nadir was increased by 66%, peak insulin was reduced by 57%, and neuroglycopenic symptoms were reduced by 80%. All doses were well tolerated with no treatment\u2010emergent adverse events observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Injection s.c. of Ex\u20109 appears to represent a safe, effective and targeted therapeutic approach for treatment of PBH. Further investigation involving multiple doses with chronic dosing is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13078","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T07:24:07Z","timestamp":1501831447000},"page":"352-361","source":"Crossref","is-referenced-by-count":46,"title":["Efficacy and pharmacokinetics of subcutaneous exendin (9\u201039) in patients with post\u2010bariatric hypoglycaemia"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-6440","authenticated-orcid":false,"given":"Colleen M.","family":"Craig","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine Stanford University School of Medicine  Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010fen","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine Stanford University School 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