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Despite the established role played by the exchanger in experimental studies, it has not been specifically targeted by those seeking to develop novel pharmacological treatments for diabetes. This review demonstrates that many existing drugs that are commonly prescribed to patients with diabetes act on the NHE1 and NHE3 isoforms in the kidney. This action may explain their effects on sodium excretion, albuminuria and the progressive decline of glomerular function in clinical trials; these responses cannot be readily explained by the influence of these drugs on blood glucose. Agents that may affect the kidney in diabetes by virtue of an action on NHE include: (1) insulin and insulin sensitizers; (2) incretin\u2010based agents; (3) sodium\u2010glucose cotransporter 2 inhibitors; (4) antagonists of the renin\u2010angiotensin system (angiotensin converting\u2010enzyme inhibitors, angiotensin receptor blockers and angiotensin receptor neprilysin inhibitors); and (5) inhibitors of aldosterone action and cholesterol synthesis (spironolactone, amiloride and statins). The renal effects of each of these drug classes in patients with type 2 diabetes may be related to a single shared biological mechanism.<\/jats:p>","DOI":"10.1111\/dom.13191","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T10:36:49Z","timestamp":1512988609000},"page":"800-811","source":"Crossref","is-referenced-by-count":12,"title":["Role of the sodium\u2010hydrogen exchanger in mediating the renal effects of drugs commonly used in the treatment of type 2 diabetes"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1828-2387","authenticated-orcid":false,"given":"Milton","family":"Packer","sequence":"first","affiliation":[{"name":"Baylor Heart and Vascular Institute Baylor University Medical Center  Dallas 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