{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:42:58Z","timestamp":1770039778988,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health and Welfare, Republic of Korea"},{"DOI":"10.13039\/100004339","name":"Sanofi-Aventis","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine the effects of early intensive glycaemic control with intensive insulin treatment (IIT) or initial combined oral antidiabetic drug (COAD) therapy on long\u2010term glycaemic control and the preservation of \u03b2\u2010cell function in people with type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Newly diagnosed drug\u2010na\u00efve patients with T2DM from 8 outpatient diabetes centres were randomized to receive either IIT (\n                      <jats:italic>n<\/jats:italic>\n                      = 50; glargine\/glulisine) or COAD (\n                      <jats:italic>n<\/jats:italic>\n                      = 47; glimepiride\/metformin) as intensive treatment until the termination criteria to ensure euglycaemia were met. After intensive treatment, the patients completed a follow\u2010up period with either lifestyle modification (LSM) alone or rescue therapy to maintain target glycated haemoglobin levels of &lt;7% (53 mmol\/mol) up to week 104. The primary outcomes were analysed after excluding participants who were anti\u2010glutamic acid decarboxylase autoantibody\u2010positive.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both intensive treatment methods were effective for short\u2010term glycaemic control, but improvements in the disposition index (DI) were significantly greater in the IIT group than in the COAD group (\n                      <jats:italic>P<\/jats:italic>\n                      = .021). During the follow\u2010up period after intensive treatment, the two groups significantly differed in rescue method regarding the maintenance of comparable levels of glycaemic control (\n                      <jats:italic>P<\/jats:italic>\n                      = .010) and more participants who received IIT exhibited well\u2010controlled glycaemia with LSM alone. Additionally, the IIT group maintained a higher DI than the COAD group during the follow\u2010up period. Cox regression analysis showed that the IIT method was associated with a 52.5% lower risk of failing to maintain drug\u2010free glycaemic remission compared with the COAD method (\n                      <jats:italic>P<\/jats:italic>\n                      = .015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings indicate that outpatient clinic\u2010based IIT to ensure euglycaemia in newly diagnosed patients with T2DM might be an effective initial therapeutic option for improvements in \u03b2\u2010cell function and glycaemic control over the long term, without serious adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.13196","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T04:24:31Z","timestamp":1514089471000},"page":"1121-1130","source":"Crossref","is-referenced-by-count":28,"title":["Long\u2010term effects on glycaemic control and \u03b2\u2010cell preservation of early intensive treatment in patients with newly diagnosed type 2 diabetes: A multicentre randomized trial"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5921-2989","authenticated-orcid":false,"given":"Suk","family":"Chon","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Kyung Hee University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Youl","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kyung Hee University School of Medicine  Seoul 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